Analysis of the role of RecQ helicases in RNAi in mammals

被引：8
|
作者：
Stein, P
Svoboda, P
Stumpo, DJ
Blackshear, PJ
Lombard, DB
Johnson, B
Schultz, RM
机构：
[1] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[3] NIEHS, Off Clin Res, Res Triangle Pk, NC 27709 USA
[4] NIEHS, Lab Signal Transduct, Res Triangle Pk, NC 27709 USA
[5] MIT, Dept Biol, Cambridge, MA 02139 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2002年 / 291卷 / 05期
关键词：
D O I：
10.1006/bbrc.2002.6578
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The identity of mammalian genes involved in RNA interference (RNAi), the targeted sequence-specific mRNA degradation by double-stranded RNA (dsRNA), is poorly defined. Here we report the analysis of mice with null mutations of Wrn, Blm, and RecQ1 genes that are related to Mut-7 and Qde3, two genes essential for RNAi in Caenorhabditis elegans and quelling in Neurospora, respectively. Our results suggest that Wrn, Blm, and RecQ1 are not involved in sequence-specific mRNA degradation in mammals in response to dsRNA, suggesting potential differences in the mammalian RNAi pathway. (C) 2002 Elsevier Science (USA).
引用
收藏
页码：1119 / 1122
页数：4
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