Optimal control for fermentative production of fructo-oligosaccharides in fed-batch bioreactor

被引：11
|
作者：
Schorsch, J. [1 ]
Castro, C. C. [2 ]
Couto, L. D. [1 ]
Nobre, C. [3 ]
Kinnaert, M. [1 ]
机构：
[1] Univ Libre Bruxelles, SAAS Dept, CP 165-55, B-1050 Brussels, Belgium
[2] Univ Mons, Biosci Inst, Appl Chem & Biochem Dept, 56 Rue Epargne, B-7000 Mons, Belgium
[3] Univ Minho, Ctr Biol Engn, Campus Gualtar, P-4710057 Braga, Portugal
来源：
JOURNAL OF PROCESS CONTROL | 2019年 / 78卷
关键词：
Optimal control; Maximum principle of Pontryagin; Fructo-oligosaccharides; Fed-batch bioreactor; MIXED-ENZYME SYSTEM; BETA-FRUCTOFURANOSIDASE; MATHEMATICAL-MODEL; FRUCTOOLIGOSACCHARIDES; SUCROSE; FRUCTOSYLTRANSFERASE; GALACTOSIDASE; PURIFICATION; OPERATION; REACTORS;
D O I：
10.1016/j.jprocont.2019.03.004
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
The production of high-content fructo-oligosaccharides by fermentation in a fed-batch bioreactor is considered. Fed-batch scenario allows to reduce inhibition mechanisms caused by the presence of by-products, such as glucose, while maximizing biomass production. The determination of the feed flow rate profile that maximizes the concentration of fructo-oligosaccharides is performed by resorting to the maximum principle of Pontryagin. The optimization procedure takes into account inequality constraints on the state and control variables and allows the determination of the unspecified final fermentation time corresponding to maximal fructo-oligosaccharides content. The performance of the approach is demonstrated by simulations in the case of fructo-oligosaccharide production by Aspergillus sp. (C) 2019 Elsevier Ltd. All rights reserved.
引用
收藏
页码：124 / 138
页数：15
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