Anxiety disorders are associated with early onset of heroin use and rapid transition to dependence in methadone maintained patients

被引：4

作者：

Karsinti, Emily ^{[1
,2
,3
,4
]}

Fortias, Maeva ^{[1
,2
,3
,4
]}

Dupuy, Gael ^{[1
,2
,3
,4
]}

Ksouda, Kamilia ^{[5
]}

Laqueille, Xavier ^{[6
]}

Simonpoli, Anne-Marie ^{[7
]}

Touzeau, Didier ^{[8
]}

Avril, Elisabeth ^{[9
]}

Orizet, Cyrille ^{[10
]}

Belforte, Beatriz ^{[10
]}

Coeuru, Philippe ^{[11
]}

Polomeni, Pierre ^{[12
]}

Icick, Romain ^{[1
,2
,3
,4
]}

Jarroir, Marine ^{[1
,2
,3
,4
]}

Bloch, Vanessa ^{[2
,3
,4
]}

Scott, Jan ^{[13
,14
]}

Lepine, Jean-Pierre ^{[1
,2
,3
,4
]}

Bellivier, Frank ^{[1
,2
,3
,4
]}

Vorspan, Florence ^{[1
,2
,3
,4
]}

机构：

[1] Hop Fernand Widal, APHP, Dept Psychiat & Med Addictol, Paris, France

[2] INSERM, U1144, F-75006 Paris, France

[3] Univ Paris 05, UMR S 1144, F-75006 Paris, France

[4] Univ Paris Diderot, UMR S 1144, Sorbonne Paris Cite, F-75013 Paris, France

[5] Fac Med Sfax, Lab Pharmacol, Sfax, Tunisia

[6] Ctr Hosp St Anne, Serv Addictol, 1 Rue Cabanis, Paris, France

[7] Hop Louis Mourier, APHP, Colombes, France

[8] Hop Paul Guiraud, APHP, CSAPA Clin Liberte, Ivry, France

[9] Assoc GAIA, Paris, France

[10] Hop Europeen Georges Pompidou, APHP, CSAPA Monte Cristo, Paris, France

[11] Assoc Aurore, CSAPA EGO, Paris, France

[12] CSAPA 110 Halles, Paris, France

[13] Newcastle Univ, Acad Psychiat, Inst Neurosci, Newcastle Upon Tyne, Tyne & Wear, England

[14] Inst Psychiat, Ctr Affect Disorders, London, England

来源：

PSYCHIATRY RESEARCH | 2016年 / 245卷

关键词：

Heroin; Cannabis; Methadone; Transition; Risk factors; Pathways; UTAH RATING-SCALE; INTERVIEW; INITIATION; RATIONALE; PATTERNS;

D O I：

10.1016/j.psychres.2016.04.064

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Early onset of heroin use is a severity marker of heroin use disorder. We studied the interaction between early onset and rapid transition to heroin dependence recorded with retrospective interviews in 213 patients with severe heroin dependence and history of methadone maintenance treatment. General linear models were used to identify independent factors associated with early onset, factors associated with rapid transition to dependence, and a multivariate model was used to study the interaction of those two dimensions. Lifetime history of anxiety disorders and age at onset of cannabis use are shared common risk factors and are associated with the interaction. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：423 / 426

页数：4

共 41 条

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