AAV Gene Therapy with Cholesterol 24-Hydroxylase for Alzheimer Disease: In Vivo Consequences on Amyloid and Tau Components of the Pathology

被引：0

作者：

Gautier, Benoit ^{[1
]}

Burlot, Marie Anne ^{[1
]}

Blum, David ^{[2
]}

Hudry, Eloise ^{[1
]}

Ayciriex, Sophie ^{[3
]}

Troquier, L. ^{[2
]}

Zommer, N. ^{[2
]}

Caillerez, R. ^{[2
]}

Auzeil, Vincent ^{[3
]}

Braudeau, Jerome ^{[1
]}

Laprevote, Olivier ^{[3
]}

Pradier, Laurent

Aubourg, Patrick ^{[1
]}

Buee, Luc ^{[2
]}

Cartier, Nathalie ^{[1
]}

机构：

[1] Univ Paris 05, INSERM, UMR745, Paris, France

[2] Univ Lille 2, INSERM, UMR837, F-59800 Lille, France

[3] Univ Paris 05, Lab Chim Toxicol Analyt & Cellulaire C TAC EA 446, Paris, France

来源：

MOLECULAR THERAPY | 2012年 / 20卷

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

引用

页码：S30 / S31

页数：2

共 28 条

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[22] Association Between Visual Memory and In Vivo Amyloid and Tau Pathology in Preclinical Autosomal Dominant Alzheimer's Disease
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[24] Amyloid-β-induced disruption of axon-initial-segment mitochondria localization: consequences for TAU missorting in Alzheimer's disease pathology
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[25] Association between a T/C polymorphism in intron 2 of cholesterol 24S-hydroxylase gene and Alzheimer's disease in Chinese
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[26] Polymorphism in the cholesterol 24S-hydroxylase gene (CYP46A1) associated with the APOEε3 allele increases the risk of Alzheimer's disease and of mild cognitive impairment progressing to Alzheimer's disease
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[28] AAVrh.10 delivery of the combined E2 and Christchurch gain-of-function variants of the human APOE gene effectively suppresses both amyloid and Tau pathology in the CNS of murine models of APOE4 homozygote Alzheimer's Disease
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