Solid-State Catalytic Hydrogen/Deuterium Exchange in Mexidol

被引：3

作者：

Dadayan, A. K. ^{[1
]}

Borisov, Yu A. ^{[2
]}

Zolotarev, Yu A. ^{[1
]}

Bocharov, E., V ^{[3
]}

Nagaev, I. Yu ^{[1
]}

Myasoedov, N. F. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia

[2] Russian Acad Sci, Nesmeyanov Inst Organoelement Cpds, Moscow 119991, Russia

[3] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

来源：

RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A | 2021年 / 95卷 / 02期

关键词：

solid-state catalytic reaction; reaction mechanism; hydrogen spillover; quantum chemistry; NMR spectroscopy; SPILLOVER HYDROGEN; ISOTOPE-EXCHANGE; CO;

D O I：

10.1134/S0036024421020096

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The reaction between spillover hydrogen (SH) and mexidol upon high-temperature solid state catalytic isotope exchange (HSCIE) is studied experimentally and via DFT B3LYP and MP2 calculations. The distribution of isotopes and the activation energy of the reaction are determined via NMR spectro-scopy and mass spectrometry for samples of the deuterium-labeled mexidol obtained via HSCIE at 50-120 degrees C. The DFT calculated activation energy of hydrogen transfer on the charged alumina cluster HH+(-Al-O-)(3)(OH)(6) is found to agree with the experimental data. A mechanism is proposed for HSCIE between the adsorbed compound and charged Bronsted acid sites formed on the surface of the support upon exposure to hydrogen spillover.

引用

页码：273 / 278

页数：6

共 50 条

[21] Solid-State Hydrogen Deuterium Exchange Mass Spectrometry: Correlation of Deuterium Uptake and Long-Term Stability of Lyophilized Monoclonal Antibody Formulations
Moorthy, Balakrishnan S.
Zarraga, Isidro E.
Kumar, Lokesh
Walters, Benjamin T.
Goldbach, Pierre
Topp, Elizabeth M.
Allmendinger, Andrea
MOLECULAR PHARMACEUTICS, 2018, 15 (01) : 1 - 11
[22] Stability of antibody drug conjugate formulations evaluated using solid-state hydrogen-deuterium exchange mass spectrometry
Cho, Eunbi
Mayhugh, Brendan M.
Srinivasan, Jayasree M.
Sacha, Gregory A.
Nail, Steven L.
Topp, Elizabeth M.
JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 110 (06) : 2379 - 2385
[23] Study of solid-state catalytic isotope exchange of hydrogen inl-hydroxyproline under the action of spillover tritium
Yu. A. Zolotarev
Yu. A. Borisov
Russian Chemical Bulletin, 1999, 48 : 1044 - 1048
[24] Study of solid-state catalytic isotope exchange of hydrogen in L-hydroxyproline under the action of spillover tritium
Zolotarev, YA
Borisov, YA
RUSSIAN CHEMICAL BULLETIN, 1999, 48 (06) : 1044 - 1048
[25] Measurement of backbone hydrogen-deuterium exchange in the type III secretion system needle protein PrgI by solid-state NMR
Chevelkov, Veniamin
Giller, Karin
Becker, Stefan
Lange, Adam
JOURNAL OF MAGNETIC RESONANCE, 2017, 283 : 110 - 116
[26] Investigation of the Solid-State Interactions in Lyophilized Human G-CSF Using Hydrogen-Deuterium Exchange Mass Spectrometry
Wood, Victoria E.
Kellerman, Mark-Adam
Groves, Kate
Quaglia, Milena
Topp, Elizabeth M.
Matejtschuk, Paul
Dalby, Paul A.
MOLECULAR PHARMACEUTICS, 2024, 21 (04) : 1965 - 1976
[27] Study of the solid-state hydrogen isotope exchange ofl-alanine
Yu. A. Zolotarev
E. V. Laskatelev
V. S. Kozik
E. M. Dorokhova
S. G. Rozenberg
Yu. A. Borisov
N. F. Myasoedov
Russian Chemical Bulletin, 1997, 46 : 726 - 731
[28] Solid-state isotopic exchange with spillover-hydrogen in proteins and peptides
Zolotarev, Yu. A.
Vaskovsky, B. V.
Dadayan, A. K.
Kozik, V. S.
Ziganshin, R. H.
Myasoedov, N. F.
JOURNAL OF PEPTIDE SCIENCE, 2006, 12 : 207 - 207
[29] SOLID-STATE DEUTERIUM NMR OF ACRYLATE POLYMERS
COLLETTI, RF
MATHIAS, LJ
SPIESS, HW
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1989, 197 : 151 - POLY
[30] SOLID-STATE DEUTERIUM NMR OF PERFLUORODECYL DECANE
JARIWALA, CP
COLLETTI, RF
JARRETT, WL
GRIFFIN, AC
MATHIAS, LJ
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1991, 201 : 1 - MACR

← 1 2 3 4 5 →