Clinicopathological significance of Notch1 expression in cervical cancer patients: a meta-analysis

被引：3

作者：

Song, Lingxie ^{[1
,2
]}

Meng, Lian ^{[1
,2
]}

Peng, Jifeng ^{[1
,2
]}

Wang, Ping ^{[1
,2
]}

Qi, Shengnan ^{[1
,2
]}

Li, Wanyu ^{[1
,2
]}

Liu, Chunxia ^{[1
,2
,3
]}

Li, Feng ^{[1
,2
,3
]}

机构：

[1] Shihezi Univ, Dept Pathol, Sch Med, Shihezi 832002, Xinjiang, Peoples R China

[2] Chinese Minist Educ, Key Labs Xinjiang Endem & Ethn Dis, Shihezi 832002, Xinjiang, Peoples R China

[3] Shihezi Univ, Sch Med, Dept Pathol, Affiliated Hosp 1, Xinjiang 832002, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 01期

基金：

中国国家自然科学基金;

关键词：

cervical cancer; clinicopathological parameters; expression; meta-analysis; Notch1; HUMAN-PAPILLOMAVIRUS; BREAST-CANCER; KAPPA-B; GROWTH; PROGNOSIS; INVASION; TARGET; CELLS;

D O I：

10.2217/bmm.15.103

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: Notch1 expression remains incompatible and contradictory with previous findings on cervical cancer. The purpose of this study is to evaluate the association between Notch1 and cervical cancer. Methods: Available studies were searched from diverse databases and Review Managers 5.3 software was used to perform analysis. Results: A total of 798 samples were included in this meta-analysis. The Notch1 expression in cancer tissues was higher than that in precancer (p = 0.0003) and normal tissues (p < 0.02). However, the difference of Notch1 expression between cancer cases and precancer cases has no statistical significance (p = 0.35). Moreover, lymph node metastasis (p = 0.02) was associated with higher Notch1 expression in cervical cancer. Conclusion: Notch1 over-expression indicated aggressive biological behaviors.

引用

页码：63 / 72

页数：10

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