Clinicopathological significance of Notch1 expression in cervical cancer patients: a meta-analysis

被引：3
|
作者：
Song, Lingxie [1 ,2 ]
Meng, Lian [1 ,2 ]
Peng, Jifeng [1 ,2 ]
Wang, Ping [1 ,2 ]
Qi, Shengnan [1 ,2 ]
Li, Wanyu [1 ,2 ]
Liu, Chunxia [1 ,2 ,3 ]
Li, Feng [1 ,2 ,3 ]
机构：
[1] Shihezi Univ, Dept Pathol, Sch Med, Shihezi 832002, Xinjiang, Peoples R China
[2] Chinese Minist Educ, Key Labs Xinjiang Endem & Ethn Dis, Shihezi 832002, Xinjiang, Peoples R China
[3] Shihezi Univ, Sch Med, Dept Pathol, Affiliated Hosp 1, Xinjiang 832002, Peoples R China
来源：
BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 01期
基金：
中国国家自然科学基金;
关键词：
cervical cancer; clinicopathological parameters; expression; meta-analysis; Notch1; HUMAN-PAPILLOMAVIRUS; BREAST-CANCER; KAPPA-B; GROWTH; PROGNOSIS; INVASION; TARGET; CELLS;
D O I：
10.2217/bmm.15.103
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: Notch1 expression remains incompatible and contradictory with previous findings on cervical cancer. The purpose of this study is to evaluate the association between Notch1 and cervical cancer. Methods: Available studies were searched from diverse databases and Review Managers 5.3 software was used to perform analysis. Results: A total of 798 samples were included in this meta-analysis. The Notch1 expression in cancer tissues was higher than that in precancer (p = 0.0003) and normal tissues (p < 0.02). However, the difference of Notch1 expression between cancer cases and precancer cases has no statistical significance (p = 0.35). Moreover, lymph node metastasis (p = 0.02) was associated with higher Notch1 expression in cervical cancer. Conclusion: Notch1 over-expression indicated aggressive biological behaviors.
引用
收藏
页码：63 / 72
页数：10
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