Self-assembled DNA nanocentipedes as multivalent vehicles for enhanced delivery of CpG oligonucleotides

被引：34
|
作者：
Li, Wenshan [1 ]
Luo, Lei [1 ]
Huang, Jin [1 ]
Wang, Qing [1 ]
Liu, Jianbo [1 ]
Xiao, Xiao [1 ]
Fang, Hongmei [1 ]
Yang, Xiaohai [1 ]
Wang, Kemin [1 ]
机构：
[1] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn, Key Lab Bionanotechnol & Mol Engn Hunan Prov, Changsha 410082, Hunan, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 40期
关键词：
INTRACELLULAR DELIVERY; CANCER-IMMUNOTHERAPY; CHECKPOINT BLOCKADE; STRUCTURAL BASIS; IMMUNE CELLS; IN-VIVO; ANTITUMOR; NANOSTRUCTURES; RECOGNITION; NANOAGENTS;
D O I：
10.1039/c7cc01128h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report self-assembled nanocentipedes as multivalent vehicles for the delivery of immunostimulatory CpG ODNs. The multivalent vehicles could be internalized by RAW264.7 cells and stimulate the secretion of large amounts of cytokines, successively inducing effective apoptosis of cancer cells.
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页码：5565 / 5568
页数：4
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