Self-assembled DNA nanocentipedes as multivalent vehicles for enhanced delivery of CpG oligonucleotides

被引：34
|
作者：
Li, Wenshan [1 ]
Luo, Lei [1 ]
Huang, Jin [1 ]
Wang, Qing [1 ]
Liu, Jianbo [1 ]
Xiao, Xiao [1 ]
Fang, Hongmei [1 ]
Yang, Xiaohai [1 ]
Wang, Kemin [1 ]
机构：
[1] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn, Key Lab Bionanotechnol & Mol Engn Hunan Prov, Changsha 410082, Hunan, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 40期
关键词：
INTRACELLULAR DELIVERY; CANCER-IMMUNOTHERAPY; CHECKPOINT BLOCKADE; STRUCTURAL BASIS; IMMUNE CELLS; IN-VIVO; ANTITUMOR; NANOSTRUCTURES; RECOGNITION; NANOAGENTS;
D O I：
10.1039/c7cc01128h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report self-assembled nanocentipedes as multivalent vehicles for the delivery of immunostimulatory CpG ODNs. The multivalent vehicles could be internalized by RAW264.7 cells and stimulate the secretion of large amounts of cytokines, successively inducing effective apoptosis of cancer cells.
引用
下载
收藏
页码：5565 / 5568
页数：4
相关论文
共 50 条
  • [1] Self-Assembled Multivalent DNA Nanostructures for Noninvasive Intracellular Delivery of Immunostimulatory CpG Oligonucleotides
    Li, Jiang
    Pei, Hao
    Zhu, Bing
    Liang, Le
    Wei, Min
    He, Yao
    Chen, Nan
    Li, Di
    Huang, Qing
    Fan, Chunhai
    ACS NANO, 2011, 5 (11) : 8783 - 8789
  • [2] Self-Assembled DNA Immunonanoflowers as Multivalent CpG Nanoagents
    Zhang, Liqin
    Zhu, Guizhi
    Mei, Lei
    Wu, Cuichen
    Qiu, Liping
    Cui, Cheng
    Liu, Yuan
    Teng, I-Ting
    Tan, Weihong
    ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (43) : 24069 - 24074
  • [3] Self-Assembled DNA Nanocentipede as Multivalent Drug Carrier for Targeted Delivery
    Li, Wenshan
    Yang, Xiaohai
    He, Leiliang
    Wang, Kemin
    Wang, Qing
    Huang, Jin
    Liu, Jianbo
    Wu, Bin
    Xu, Congcong
    ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (39) : 25733 - 25740
  • [4] Self-Assembled DNA Dendrimer Nanoparticle for Efficient Delivery of Immunostimulatory CpG Motifs
    Qu, Yijiao
    Yang, Juanjuan
    Zhan, Pengfei
    Liu, Shaoli
    Zhang, Kun
    Jiang, Qiao
    Li, Can
    Ding, Baoquan
    ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (24) : 20324 - 20329
  • [5] Adsorption of DNA Oligonucleotides by Self-Assembled Metalloporphyrin Nanomaterials
    Wang, Jinghan
    Wang, Zhen
    Huang, Po-Jung Jimmy
    Bai, Feng
    Liu, Juewen
    LANGMUIR, 2022, 38 (11) : 3553 - 3560
  • [6] Targeted Delivery of Antisense Oligonucleotides by Chemically Self-Assembled Nanostructures
    Gangar, Amit
    Fegan, Adrian
    Kumarapperuma, Sidath C.
    Huynh, Peter
    Benyumov, Alexey
    Wagner, Carston R.
    MOLECULAR PHARMACEUTICS, 2013, 10 (09) : 3514 - 3518
  • [7] Self-assembled nanosystems as delivery vehicles for regenerative medicine
    Koria, Piyush
    THERAPEUTIC DELIVERY, 2012, 3 (05) : 583 - 587
  • [8] Glycopolypeptide self-assembled nanomaterials as efficient delivery systems with multivalent properties
    Lecommandoux, Sebastien
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [9] Self-Assembled DNA Nanostructures for Drug Delivery
    Jia, Ruokun
    Wang, Ting
    Jiang, Qiao
    Wang, Zhengang
    Song, Chen
    Ding, Baoquan
    CHINESE JOURNAL OF CHEMISTRY, 2016, 34 (03) : 265 - 272
  • [10] Characterization of self-assembled DNA concatemers from synthetic oligonucleotides
    Sun, Lu
    Akerman, Bjorn
    COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2014, 11 (18): : 66 - 72
12345