Severe Coronavirus Disease 2019 That Recovered from Respiratory Failure by Treatment That Included High-dose Intravenous Immunoglobulin

被引：4

作者：

Suzuki, Yasuhito ^{[1
]}

Tanino, Yoshinori ^{[1
]}

Nikaido, Takefumi ^{[1
]}

Minemura, Hiroyuki ^{[1
]}

Umeda, Takashi ^{[1
]}

Rikimaru, Mami ^{[1
]}

Onuma, Takumi ^{[1
]}

Naito, Shotaro ^{[2
]}

Takiguchi, Yoshinori ^{[3
]}

Tomita, Hikaru ^{[1
]}

Kawamata, Takaya ^{[1
]}

Togawa, Ryuichi ^{[1
]}

Sato, Yuki ^{[1
]}

Uematsu, Manabu ^{[1
]}

Morimoto, Julia ^{[1
]}

Kitakawa, Kadzuhiro ^{[4
]}

Tsukada, Yasuhiko ^{[5
]}

Nakamura, Kiwamu ^{[6
]}

Kanemitsu, Keiji ^{[6
]}

Iseki, Ken ^{[5
]}

Shibata, Yoko ^{[1
]}

机构：

[1] Fukushima Med Univ, Sch Med, Dept Pulm Med, Fukushima, Japan

[2] Fukushima Med Univ, Dept Gen Internal Med, Fukushima, Japan

[3] Fukushima Med Univ, Dept Diabet Endocrinol & Metab, Fukushima, Japan

[4] Fukushima Prefectural Inst Publ Hlth, Fukushima, Japan

[5] Fukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima, Japan

[6] Fukushima Med Univ, Dept Infect Control, Fukushima, Japan

来源：

INTERNAL MEDICINE | 2021年 / 60卷 / 03期

关键词：

coronavirus disease 2019; COVID-19; intravenous immunoglobulin; severe acute respiratory syndrome-coronavirus-2; acute respiratory distress syndrome; deterioration; COVID-19; MODULATE;

D O I：

10.2169/internalmedicine.6326-20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein report a case of severe coronavirus disease 2019 (COVID-19) in which high-dose intravenous immunoglobulin (IVIg) treatment achieved significant clinical improvement of deterioration of pulmonary inflammation after temporary clinical improvement. In the present case, clinical and radiological deterioration occurred despite a decrease in viral load, suggesting that deterioration was caused by reactivation of proinflammatory factors. such as tumor necrosis factor-a and interleukin-6, rather than direct viral effects. IVIg treatment may provide not only immunosuppressive effects but also inhibition of proinflammatory cytoldnes, indicating that treatment including IVIg may be effective by inhibiting cytokine storm in severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection.

引用

页码：457 / 461

页数：5

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