Clinical Significance of PRKCI Gene Expression in Cancerous Tissue in Patients With Gastric Cancer

被引：17

作者：

Hashimoto, Itaru ^{[1
,2
]}

Sakamaki, Kentaro ^{[3
]}

Oue, Naohide ^{[4
]}

Kimura, Yayoi ^{[5
]}

Hiroshima, Yukihiko ^{[6
]}

Hara, Kentaro ^{[1
,2
]}

Maezawa, Yukio ^{[1
]}

Kano, Kazuki ^{[2
]}

Aoyama, Toru ^{[1
,2
]}

Yamada, Takanobu ^{[2
]}

Yamamoto, Naoto ^{[2
]}

Ogata, Takashi ^{[2
]}

Ito, Hiroyuki ^{[7
]}

Shiozawa, Manabu ^{[2
]}

Morinaga, Soichiro ^{[2
]}

Rino, Yasushi ^{[1
]}

Yasui, Wataru ^{[4
]}

Masuda, Munetaka ^{[1
]}

Miyagi, Yohei ^{[6
]}

Oshima, Takashi ^{[2
]}

机构：

[1] Yokohama City Univ, Dept Surg, Yokohama, Kanagawa, Japan

[2] Kanagawa Canc Ctr, Dept Gastrointestinal Surg, Yokohama, Kanagawa 2418515, Japan

[3] Univ Tokyo, Grad Sch Med, Dept Biostat & Informat, Tokyo, Japan

[4] Hiroshima Univ, Dept Mol Pathol, Inst Biomed & Hlth Sci, Hiroshima, Japan

[5] Yokohama City Univ, Adv Med Res Ctr, Yokohama, Kanagawa, Japan

[6] Kanagawa Canc Ctr Res Inst, Yokohama, Kanagawa, Japan

[7] Kanagawa Canc Ctr, Dept Resp Surg, Yokohama, Kanagawa, Japan

来源：

ANTICANCER RESEARCH | 2019年 / 39卷 / 10期

基金：

日本学术振兴会;

关键词：

Gastric cancer; protein kinase C iota; PRKCI; KINASE-C-IOTA; PKC-IOTA; CELLS; ACTIVATION; PROGNOSIS; ONCOGENE; GROWTH;

D O I：

10.21873/anticanres.13771

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: The PRKCI gene encodes Protein kinase C iota. The overexpression of protein kinase C iota is associated with poor outcomes in patients with gastric and other cancers, but the role of the PRKCI gene in gastric cancer is not fully understood. Thus, we evaluated the clinical significance of PRKCI gene expression in gastric cancer. Materials and Methods: PRKCI mRNA expression levels in cancerous tissues and adjacent normal mucosa from 398 patients with gastric cancer were measured. Relationships between PRKCI gene expression and clinicopathological characteristics and outcomes were examined. Results: Overall survival was lower in patients with a high expression of PRKCI than in those with low expression (p=0.016). No other relationships were observed. A high PRKCI expression was found to be an independent prognostic factor (p=0.036, HR=1.44, 95% CI=1.02-2.02). Conclusion: PRKCI gene expression in cancerous tissue might be a useful prognostic factor in patients with gastric cancer after gastrectomy.

引用

页码：5715 / 5720

页数：6

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