Development of the "Diverted Heck" Reaction for the Synthesis of Five-Membered Rings

被引：2

作者：

Breitwieser, Kevin ^{[1
]}

Chen, Peter ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Lab Organ Chem, CH-8093 Zurich, Switzerland

来源：

ORGANOMETALLICS | 2021年 / 40卷 / 06期

基金：

瑞士国家科学基金会;

关键词：

ARYL; CYCLOPROPANES; MECHANISM; GENERATION; LIGANDS; OLEFINS;

D O I：

10.1021/acs.organomet.1c00025

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The "diverted Heck" reaction has been shown to be a potent method to synthesize cyclopropanes from electron-rich olefins and iodomethyl trifluoroborate. Nevertheless, it is not mechanistically limited to the three-membered rings. The synthesis of five-membered rings using bifunctional substrates with a halide moiety and an organometallic group is described. Furthermore, the reactions of the respective boron and tin-based substrates are further investigated and optimized.

引用

页码：776 / 782

页数：7

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