Development of the "Diverted Heck" Reaction for the Synthesis of Five-Membered Rings

被引：2
|
作者：
Breitwieser, Kevin [1 ]
Chen, Peter [1 ]
机构：
[1] Swiss Fed Inst Technol, Lab Organ Chem, CH-8093 Zurich, Switzerland
来源：
ORGANOMETALLICS | 2021年 / 40卷 / 06期
基金：
瑞士国家科学基金会;
关键词：
ARYL; CYCLOPROPANES; MECHANISM; GENERATION; LIGANDS; OLEFINS;
D O I：
10.1021/acs.organomet.1c00025
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The "diverted Heck" reaction has been shown to be a potent method to synthesize cyclopropanes from electron-rich olefins and iodomethyl trifluoroborate. Nevertheless, it is not mechanistically limited to the three-membered rings. The synthesis of five-membered rings using bifunctional substrates with a halide moiety and an organometallic group is described. Furthermore, the reactions of the respective boron and tin-based substrates are further investigated and optimized.
引用
收藏
页码：776 / 782
页数：7
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