Akt inhibitor SC66 promotes cell sensitivity to cisplatin in chemoresistant ovarian cancer cells through inhibition of COL11A1 expression

被引：0
|
作者：
Wu, Yi-Hui [1 ]
Chou, Cheng-Yang [1 ]
机构：
[1] Natl Cheng Kung Univ, Tainan, Taiwan
来源：
CANCER RESEARCH | 2019年 / 79卷 / 13期
关键词：
D O I：
10.1158/1538-7445.AM2019-3911
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3911
引用
收藏
页数：2
相关论文
共 30 条
  • [21] Activation of COL11A1 by anticancer drugs through IGF-1R/PI3K pathway confers chemoresistance in ovarian cancer via activating NF-κB-mediated Twist1 expression
    Wu, Yi-Hui
    Huang, Yu-Fang
    Chou, Cheng-Yang
    CANCER RESEARCH, 2014, 74 (19)
  • [22] Plk3 Enhances Cisplatin Sensitivity of Nonsmall-Cell Lung Cancer Cells through Inhibition of the PI3K/AKT Pathway via Stabilizing PTEN
    Xu, Mengshan
    Deng, Xiaoyun
    Xiang, Nana
    Zhang, Zhao
    Yang, Min
    Liu, Qinxiang
    ACS OMEGA, 2024, 9 (08): : 8995 - 9002
  • [23] DMBT1 suppresses cell proliferation, migration and invasion in ovarian cancer and enhances sensitivity to cisplatin through galectin-3/PI3k/Akt pathway
    Ma, Nan
    Zhao, Yuqing
    CELL BIOCHEMISTRY AND FUNCTION, 2020, 38 (06) : 801 - 809
  • [24] Inhibition of autophagy promotes cisplatin-induced apoptotic cell death through Atg5 and Beclin 1 in A549 human lung cancer cells
    Chen, Jianhua
    Zhang, Lemeng
    Zhou, Hui
    Wang, Wei
    Luo, Yongzhong
    Yang, Hua
    Yi, Huihuang
    MOLECULAR MEDICINE REPORTS, 2018, 17 (05) : 6859 - 6865
  • [25] Inhibition of Beclin 1 Expression Enhances Cisplatin-Induced Apoptosis Through a Mitochondrial-Dependent Pathway in Human Ovarian Cancer SKOV3/DDP Cells
    Sun, Yang
    Liu, Jia-hua
    Jin, Long
    Sui, Yu-xia
    Lai, Li
    Yang, Yin
    ONCOLOGY RESEARCH, 2013, 21 (05) : 261 - 269
  • [26] Targeted silencing of NaV1.5 channel suppresses cell proliferation and invasion in ovarian cancer cells through inhibition of PI3K/AKT and Integrinβ-1/FAK/Src axis
    Erdogan, Mumin Alper
    Ozpolat, Bulent
    CANCER RESEARCH, 2018, 78 (13)
  • [27] Transcription Factor FOSL1 Promotes Cisplatin Resistance in Non-Small Cell Lung Cancer Cells by Modulating the Wnt3a/β-Catenin Signaling through Upregulation of PLIN3 Expression
    Tong, Wanning
    Sun, Jianjun
    Shen, Bin
    Hu, Yaohua
    Wang, Chenxing
    Rao, Min
    Li, Jin
    Xia, Delin
    Dong, Jiagui
    Wang, Hong
    Zhu, Dongmei
    Wu, Haibo
    Cai, Zhigang
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2025, 30 (03):
  • [28] Surface marker and gene expression profiling of tumors from PDX models of small cell lung cancer with varying sensitivity to growth inhibition by the p70S6K/AKT1/3 inhibitor M2698
    Hahn, Friedrich
    Porter, Warren
    Snowden, Eileen
    Ferguson, Mitchell
    Tong, Frances
    Dillmore, William S.
    Clark, Anderson
    Zhang, Hong
    Blaesius, Rainer
    CANCER RESEARCH, 2018, 78 (13)
  • [29] Surface protein marker and single cell gene expression profiling of individual tumor cells dissociated from small cell lung cancer pdx mouse models can be correlated with in vivo sensitivity to the p70S6K/AKT1/3 inhibitor M2698
    Porter, Warren
    Snowden, Eileen
    Hahn, Friedrich
    Ferguson, Mitchell
    Tong, Frances
    Dillmore, William S.
    Clark, Anderson
    Zhang, Hong
    Blaesius, Rainer
    CANCER RESEARCH, 2019, 79 (13)
  • [30] Cyclic GMP/protein kinase G type-Iα (PKG-Iα) signaling pathway promotes CREB phosphorylation and maintains higher c-IAP1, livin, survivin, and Mcl-1 expression and the inhibition of PKG-Iα kinase activity synergizes with cisplatin in non-small cell lung cancer cells
    Wong, Janica C.
    Bathina, Madhavi
    Fiscus, Ronald R.
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2012, 113 (11) : 3587 - 3598
123