Three new sulfur-containing alkaloids, polycarpaurines A, B, and C, from an Indonesian ascidian Polycarpa aurata

被引：20
|
作者：
Wang, Weifang
Oda, Taiko
Fujita, Ayako
Mangindaan, Remy E. P.
Nakazawa, Takahiro
Ukai, Kazuyo
Kobayashi, Hisayoshi
Namikoshi, Michio [1 ]
机构：
[1] Tohoku Pharmaceut Univ, Dept Nat Prod Chem, Aoba Ku, Sendai, Miyagi 9818558, Japan
[2] Tokyo Univ Marine Sci & Technol, Dept Ocean Sci, Minato Ku, Tokyo 1088477, Japan
[3] Kyoritsu Univ Pharm, Fac Pharmaceut Sci, Minato Ku, Tokyo 1058512, Japan
[4] Sam Ratulangi Univ, Fac Fisheries & Marine Sci, Manado 95115, India
[5] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan
来源：
TETRAHEDRON | 2007年 / 63卷 / 02期
关键词：
Polycarpa aurata; ascidian; polycarpaurine; sulfur-containing alkaloid; structure assignment;
D O I：
10.1016/j.tet.2006.10.060
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Three new sulfur-containing alkaloids, polycarpaurines A (1), B (2), and C (3) were isolated from the tropical ascidian Polycarpa aurata collected in Indonesia, together with six known compounds (4-9). The structures of new compounds were assigned on the basis of their spectral data. Compounds 1, 3, 4, and 8 inhibited colony formation of Chinese hamster V79 cells with EC50 values of 6.8, 8.6, 3.8, and 10 PM, respectively. Compounds 2 and 7 showed modest activity against V79 cells (EC50 > 10 mu M). (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：409 / 412
页数：4
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