Subacute Effects of Capsaicinoids on the Distribution of White Blood Cells in Rats

被引：7
|
作者：
Aritoshi, Shoko [1 ]
Sato, Shogo [1 ]
Kumazawa, Mari [1 ]
Ban, Takamasa [1 ]
Tanihata, Jun [2 ]
Tachiyashiki, Kaoru [3 ]
Imaizumi, Kazuhiko [1 ]
机构：
[1] Waseda Univ, Fac Human Sci, Lab Physiol Sci, Tokorozawa, Saitama 3591192, Japan
[2] Waseda Univ, Fac Human Sci, Lab Rehabil Biomed Sci, Tokorozawa, Saitama 3591192, Japan
[3] Joetsu Univ Educ, Dept Nat & Hlth Sci, Niigata 9438512, Japan
来源：
JOURNAL OF HEALTH SCIENCE | 2010年 / 56卷 / 01期
关键词：
capsaicinoid; capsaicin; dihydrocapsaicin; white blood cell; lymphocyte; BETA(2)-AGONIST CLENBUTEROL; METABOLISM; ACTIVATION; APOPTOSIS; RECEPTOR; PAIN;
D O I：
10.1248/jhs.56.99
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
The subacute effects of dihydrocapsaincin (DHC) and capsaicin (CAP) (dose = 3 mg/kg body weight per day for 10 days, subcutaneous) on the number and distribution of white blood cells (WBCs) were studied in male adult rats. The administration of DHC and CAP for 10 days decreased significantly the number of total WBCs, lymphocytes and monocyte, and increased significantly the number of the neutrophil and eosinophil without changing the number of basophil. The administration of DHC significantly decreased thymus weight and increased adrenal weight, showing that DHC induced thymus atrophy and adrenal hypertrophy. These results suggest that capsaicinoids induced the decrease of acquired immunity responses and these phenomena may have in part participated in capsaicinoids-induced stress-responses in rats.
引用
收藏
页码：99 / 103
页数：5
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