Enhanced frontal function in Parkinson's disease

被引：104
|
作者：
Cools, R. [1 ]
Miyakawa, A. [2 ]
Sheridan, M. [3 ,4 ]
D'Esposito, M. [2 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Ctr Cognit Neuroimaging, Donders Inst Brain Cognit & Behav,Dept Psychiat, Nijmegen, Netherlands
[2] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
[3] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA
[4] Childrens Hosp, Dev Med Ctr, Boston, MA 02115 USA
来源：
BRAIN | 2010年 / 133卷
基金：
美国国家卫生研究院;
关键词：
working memory; cognitive deficits; dopamine; Parkinson's disease; basal ganglia; DELAY-PERIOD ACTIVITY; PREFRONTAL CORTEX; WORKING-MEMORY; COGNITIVE DEFICITS; BASAL GANGLIA; DOPAMINE MODULATION; CAUDATE-NUCLEUS; LESIONS; MEDICATION; MECHANISMS;
D O I：
10.1093/brain/awp301
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We investigated the role of dopamine in working memory by examining effects of withdrawing dopaminergic medication in patients with Parkinson's disease. Resistance to distraction during a delayed response task was abnormally enhanced in Parkinson's disease patients OFF medication relative to controls. Conversely, performance on a backward digit span test was impaired in these same Parkinson's disease patients OFF medication. Dopaminergic medication reinstated susceptibility to distraction and backward digit span performance, so that performance of Parkinson's disease patients ON medication did not differ from that of controls. We hypothesize that the enhanced distractor resistance and impaired backward digit span in Parkinson's disease reflects low dopamine levels in the striatum, and perhaps upregulated frontal dopamine levels. Dopaminergic medication may reinstate distractibility by normalizing the balance between striatal and prefrontal dopamine transmission.
引用
收藏
页码：225 / 233
页数：9
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