Antimicrobial and cytotoxic activities of indole alkaloids and other constituents from the stem barks of Rauvolfia caffra Sond (Apocynaceae)

被引：10
|
作者：
Bitombo, Andre Nehemie [1 ,3 ,4 ]
Zintchem, Auguste Abouem A. [1 ,2 ]
Atchade, Alex de Theodore [1 ]
Moni Ndedi, Esther Del Florence [5 ]
Kahn, Afsar [3 ]
Ngono Bikobo, Dominique Serge [1 ,4 ]
Pegnyemb, Dieudonne Emmanuel [1 ]
Bochet, Christian G. [4 ]
机构：
[1] Univ YaoundeI 1, Dept Organ Chem, Fac Sci, Yaounde, Cameroon
[2] Univ YaoundeI 1, Higher Teachers Training Coll, Dept Chem, Yaounde, Cameroon
[3] COMSATS Univ Islamabad, Dept Chem, Abbottabad, Pakistan
[4] Univ Fribourg, Dept Chem, Fribourg, Switzerland
[5] Univ Yaounde I, Dept Microbiol, Fac Sci, Yaounde, Cameroon
来源：
NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 06期
关键词：
Rauvolfia caffra; Apocynaceae; rauvolfianoids; antimicrobial activity; cytotoxicity; CHEMISTRY; L;
D O I：
10.1080/14786419.2021.1891054
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Twenty indole alkaloids, among which two undescribed ones named rauvolfianoids A (1) and B (2), were isolated from the stem barks of Rauvolfia caffra Sond along with eight other compounds from other biosynthetic pathways. The structures were elucidated by analysis of spectroscopic data, including 1 D and 2 D NMR; absolute configurations of 1 and 2 were determined by CD exciton chirality method. Compounds 1 and 2 were evaluated for antimicrobial and anticancer activities against three bacterial strains (Escherichia coli, Shigella sp and Salmonella sp) and CRC-related opportunistic pathogens. 1 showed moderate antibacterial activity against Salmonella sp with the MIC value of 25 mu g/ml, while 2 exhibited weak selective activity against all tested pathogens. In addition, these alkaloids were characterized as weak apoptosis inducers in HCT116 human colon carcinoma cell line.
引用
收藏
页码：1467 / 1475
页数：9
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