This paper is situated in the context of feminist debates around nature, culture, the body and essentialism, and focuses specifically on matter and materiality. In part, it is a response to recent developments in the natural sciences which suggest that strictly social constructionist and/or epistemological approaches to matter may be inadequate to the task of analysis and critique. It begins by considering some of the specific conditions under which the sex/gender model emerged, and its implications, before addressing the work of three contemporary theorists who are engaged with differing conceptions of matter, ontology and substance. I suggest that, while not necessarily providing 'solutions', these projects raise the kinds of questions that promise to revivify the flesh and blood of feminist critique.