Efficiency and toxmcity of the fludarabine and cyclophosphamide combined therapy in relapsed resistant patients with B-cell chronic lymphocytic leukaemia (CLL) - Polish multicenter study

被引：0
|
作者：
Kowal, M [1 ]
Dmoszynska, A [1 ]
Jawniak, D [1 ]
Lewandowski, K [1 ]
Wegrzyn, J [1 ]
Wolowiec, D [1 ]
Piszcz, J [1 ]
Roznowski, K [1 ]
机构：
[1] Med Acad, Dept Hematooncol, Lublin, Poland
来源：
7TH ANNUAL MEETING OF THE EUROPEAN HAEMATOLOGY ASSOCIATION | 2002年
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中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We present results of the fludarabine and cyclophosphamide regimen in relapsed/resistant 63 patients with CLL-the first Polish multi- centre trial. Purine analogues (PA) such as fludarabine (F) induce higher remission rates(RR) than conventional chemotherapy in advanced CLL, particulary in patients resistant to alkylating agents (AA)(3, 4). Further studies showed a synergistic activity with other drugs in particular cyclophosphamide (C)(8). The combination of F and C seem to produce a high RR in patients refractory to AA or single-agent of PA. We report here the results of first Polish multicenter study of FC regimen in patients with advanced B-CLL.
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页码：211 / 214
页数：4
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