Profiling of gene expression associated with hepatolithiasis by complementary DNA expression array

被引：2

作者：

Kokuryo, T

Yamamoto, T

Oda, K

Kamiya, J

Nimura, Y

Senga, T

Yasuda, Y

Ohno, Y

Nakanuma, Y

Chen, MF

Jan, YY

Yeh, TS

Chiu, CT

Hsieh, LL

Hamaguchi, M

机构：

[1] Nagoya Univ, Grad Sch Med, Div Surg Oncol, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Nagoya Univ, Grad Sch Med, Dept Mol Pathogenesis, Showa Ku, Nagoya, Aichi 4668550, Japan

[3] Nagoya Univ, Grad Sch Med, Dept In Home Med, Showa Ku, Nagoya, Aichi 4668550, Japan

[4] Nagoya Univ, Grad Sch Med, Dept Prevent Med Biostat & Med Decis Making, Showa Ku, Nagoya, Aichi 4668550, Japan

[5] Kanazawa Univ, Grad Sch Med, Dept Human Pathol, Kanazawa, Ishikawa 9208641, Japan

[6] Chang Gumg Univ, Chang Gung Mem Hosp, Dept Surg, Taipei 105, Taiwan

[7] Chang Gumg Univ, Chang Gung Mem Hosp, Dept Gastroenterol, Taipei 105, Taiwan

[8] Chang Gumg Univ, Chang Gung Mem Hosp, Dept Publ Hlth, Taipei 105, Taiwan

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2003年 / 22卷 / 01期

关键词：

cDNA array; hepatholithiasis; cholangiocarcinoma; tumor suppressor; proto-oncogene;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

By use of cDNA expression array method, we compared the expression profiles of genes in hepatolithiasis tissues with those of paired normal tissues. Expression of 1176 cancer related genes that include 33 tumor suppressor genes, 100 proto-oncogenes and 37 DNA damage repair genes were examined in this study. We found that expression of tumor suppressor genes and proto-oncogenes was systemically activated in hepatholithiasis tissues, suggesting that expression of genes controlling cell growth becomes unstable in liver lobe of hepatolithiasis. In contrast, expression of DNA damage repair genes were not activated but rather remained unchanged in hepatholithiasis tissues, suggesting that repair process is not strongly activated but rather impaired in hepatholithiasis tissues.

引用

页码：175 / 179

页数：5

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