Elective Nodal Irradiation for Non-small Cell Lung Cancer Complicated With Chronic Obstructive Pulmonary Disease Affects Immunotherapy Αfter Definitive Chemoradiotherapy

被引：9

作者：

Morimoto, Masahiro ^{[1
]}

Nishino, Kazumi ^{[2
]}

Wada, Kentaro ^{[1
]}

Imamura, Fumio ^{[2
]}

Konishi, Koji ^{[1
]}

Kuhara, Hanako ^{[2
]}

Tamiya, Motohiro ^{[2
]}

Inoue, Takako ^{[2
]}

Kunimasa, Kei ^{[2
]}

Kimura, Madoka ^{[2
]}

Hirata, Takero ^{[3
,4
]}

Kanayama, Naoyuki ^{[1
]}

Toratani, Masayasu ^{[1
]}

Kawachi, Hayato ^{[2
]}

Ohira, Kika ^{[2
]}

Nakanishi, Erina ^{[1
,4
]}

Ohira, Shingo ^{[1
]}

Sagawa, Tomohiro ^{[1
]}

Miyazaki, Masayoshi ^{[1
]}

Matsunaga, Takashi ^{[3
]}

Kumagai, Toru ^{[2
]}

Teshima, Teruki ^{[1
]}

机构：

[1] Osaka Int Canc Inst, Dept Radiat Oncol, Osaka, Japan

[2] Osaka Int Canc Inst, Dept Thorac Oncol, Osaka, Japan

[3] Osaka Int Canc Inst, Dept Med Informat, Osaka, Japan

[4] Osaka Univ, Dept Radiat Oncol, Grad Sch Med, Osaka, Japan

来源：

ANTICANCER RESEARCH | 2020年 / 40卷 / 12期

关键词：

Volumetric modulated arc therapy (VMAT); intensity modulated radiation therapy (IMRT); involved field radiotherapy irradiation (IFR-IFI); twice-daily thoracic radiotherapy (BID-TRT); accelerated hyperfractionated thoracic radiotherapy (AHTRT); anti-programmed cell death ligand-1 immune checkpoint inhibitor (ICIs); CONCURRENT CHEMOTHERAPY; STAGE IIIA; RADIATION; RADIOTHERAPY; SURVIVAL; COPD;

D O I：

10.21873/anticanres.14720

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: The aim of this retrospective study was to detect the frequency, reasons, and significant factors for not receiving immunotherapy after chemoradiotherapy in non-small cell lung cancer (NSCLC) patients. Patients and Methods: Thirty-four patients with NSCLC received definitive chemoradiotherapy. The endpoint of this study was receiving durvalumab within 45 days after chemoradiotherapy for NSCLC. Results: Twenty-five of 34 (73%) patients received immunotherapy within 45 days after chemoradiotherapy. The reasons for not receiving immunotherapy were radiation pneumonitis (50%), radiation esophagitis (10%), and four other reasons (40%). Univariate analysis showed that significant factors for not receiving immunotherapy were elective nodal irradiation (ENI)+ and chronic obstructive pulmonary disease (COPD)+. The rate of immunotherapy was 100% (17/17 cases) in the COPD- and ENI- group, and 16% (1/6 cases) in the COPD+ and ENI+ group. Conclusion: ENI for NSCLC complicated with COPD decreased the rate of immunotherapy after definitive chemoradiotherapy.

引用

页码：6957 / 6970

页数：14

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