Diastereoselective synthesis of (5R,7R)- and (5R,7S)-5,7-dimethyl-6,7-dihydro-5H-dibenz[c,e]azepines

被引：0
|
作者：
Saudan, LA [1 ]
Bernardinelli, G [1 ]
Kündig, EP [1 ]
机构：
[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland
来源：
SYNLETT | 2000年 / 04期
关键词：
diastereoselective imine alkylation; chiral azepine; Stille biaryl coupling; palladium; enantioselective lithiation;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Starting from (R)-1-(2-methoxyphenyl)ethylamine, the title compounds were synthesized, Key steps are a diastereoselective imine alkylation and a Pd-catalyzed biaryl coupling. The benzylic stereogenic centers of the (5R,7R)-azepine induce a strong bias for the atropisomeric conformer having aS axial chirality and pseudo equatorial Me groups.
引用
收藏
页码：483 / 486
页数：4
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