Asymmetric α-Amination of Aldehydes and Ketones Catalyzed by tert-Butoxy-L-Proline

被引：14

作者：

Ait-Youcef, Ramzi ^{[1
]}

Kalch, Delphine ^{[1
]}

Moreau, Xavier ^{[1
]}

Thomassigny, Christine ^{[1
]}

Greck, Christine ^{[1
]}

机构：

[1] Univ Versailles St Quentin En Yvelines, Inst Lavoisier Versailles, CNRS, UMR 8180, F-78035 Versailles, France

来源：

LETTERS IN ORGANIC CHEMISTRY | 2009年 / 6卷 / 05期

关键词：

Electrophilic amination; organocatalysis; tert-butoxyproline; azodicarboxylate; alpha-hydrazinoalcohol; ELECTROPHILIC AMINATION; CARBONYL-COMPOUNDS; ORGANOCATALYSIS; ACID; CARBANIONS;

D O I：

10.2174/157017809788681293

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric electrophilic alpha-amination of aldehydes and ketones is described using trans-3-tert-butoxy-L-proline and trans-4-tert-butoxy-L-proline as efficient catalysts. Good yields and high enantioselectivities are obtained working at 0 degrees C or at room temperature with a catalyst loading of only 5 mol%.

引用

页码：377 / 380

页数：4

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