MPS1 (TTK) kinase inhibition selectively kills aneuploid cells

被引：0
|
作者：
Rawjee, Teeara
Rowlands, Martin
McAndrew, Craig
Stubbs, Mark
Lord, Christopher J.
Reis-Filho, Jorge S.
Ashworth, Alan
Aherne, Wynne
Workman, Paul
Blagg, Julian
Linardopoulos, Spyridon
机构：
来源：
MOLECULAR CANCER THERAPEUTICS | 2009年 / 8卷 / 12期
关键词：
D O I：
10.1158/1535-7163.TARG-09-A239
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A239
引用
收藏
页数：2
相关论文
共 50 条
  • [41] Structural and Functional Characterization of the Protein Kinase Mps1 in Arabidopsis thaliana
    Gamosa de Oliveira, Eduardo Alves
    Romeiro, Nelilma Correia
    Ribeiro, Elane da Silva
    Santa-Catarina, Claudete
    Amancio Oliveira, Antonia Elenir
    Silveira, Vanildo
    de Souza Filho, Goncalo Apolinario
    Venancio, Thiago Motta
    Lopes Cruz, Marco Antonio
    PLOS ONE, 2012, 7 (09):
  • [42] Autophosphorylation is sufficient to release Mps1 kinase from native kinetochores
    Koch, Lori B.
    Opoku, Kwaku N.
    Deng, Yi
    Barber, Adrienne
    Littleton, Aimee J.
    London, Nitobe
    Biggins, Sue
    Asbury, Charles L.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (35) : 17355 - 17360
  • [43] Mps1 is a kinetochore associated kinase essential for the vertebrate mitotic checkpoint
    Abrieu, A
    Magnaghi-Jaulin, L
    Kahana, JA
    Peter, M
    Castro, A
    Vigneron, S
    Lorca, T
    Cleveland, DW
    Labbe, JC
    MOLECULAR BIOLOGY OF THE CELL, 2001, 12 : 409A - 409A
  • [44] Stable aneuploid cells are more sensitive to TTK inhibition than chromosome instable cell lines
    Libouban, Marion A. A.
    de Roos, Jeroen A. D. M.
    Uitdehaag, Joost C. M.
    Willemsen-Seegers, Nicole
    Mainardi, Sara
    Dylus, Jelle
    de Man, Jos
    Tops, Bastiaan
    Meijerink, Jules P. P.
    Storchova, Zuzana
    Buijsman, Rogier C.
    Medema, Rene H.
    Zaman, Guido J. R.
    CANCER RESEARCH, 2017, 77
  • [45] Naturally occurring mutations in the MPS1 gene predispose cells to kinase inhibitor drug-resistance
    Gurden, Mark D.
    Westwood, Isaac
    Faisal, Amir
    Naud, SBastien
    Cheung, Jack
    McAndrew, Craig
    Wood, Amy
    Schmitt, Jessica
    Boxall, Kathy
    Mak, Grace
    Workman, Paul
    Burke, Rosemary
    Hoelder, Swen
    Blagg, Julian
    Van Montfort, Rob
    Linardopoulos, Spiros
    CANCER RESEARCH, 2015, 75
  • [46] TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability
    Choi, Minji
    Min, Yoo Hong
    Pyo, Jaehyuk
    Lee, Chang-Woo
    Jang, Chang-Young
    Kim, Ja-Eun
    BRITISH JOURNAL OF PHARMACOLOGY, 2017, 174 (12) : 1810 - 1825
  • [47] Novel Mps1 kinase inhibitors with potent anti-tumor activity
    Wengner, Antje Margret
    Siemeister, Gerhard
    Koppitz, Marcus
    Schulze, Volker
    Kosemund, Dirk
    Klar, Ulrich
    Stoeckigt, Detlef
    Neuhaus, Roland
    Lienau, Philip
    Bader, Benjamin
    Prechtl, Stefan
    Doehr, Olaf
    Raschke, Marian
    von Ahsen, Oliver
    Elbi, Cem
    Bruns, Ingmar
    Michels, Martin
    Kreft, Bertolt
    von Nussbaum, Franz
    Brands, Michael
    Mumberg, Dominik
    Ziegelbauer, Karl
    CANCER RESEARCH, 2015, 75
  • [48] Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1
    Volker M. Stucke
    Christoph Baumann
    Erich A. Nigg
    Chromosoma, 2004, 113 : 1 - 15
  • [49] Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint
    Abrieu, A
    Magnaghi-Jaulin, L
    Kahana, JA
    Peter, M
    Castro, A
    Vigneron, S
    Lorca, T
    Cleveland, DW
    Labbé, JC
    CELL, 2001, 106 (01) : 83 - 93
  • [50] Novel Mps1 kinase inhibitors: From purine to pyrrolopyrimidine and quinazoline leads
    Bursavich, Matthew G.
    Dastrup, David
    Shenderovich, Mark
    Yager, Kraig M.
    Cimbora, Daniel M.
    Williams, Brandi
    Kumar, D. Vijay
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (24) : 6829 - 6833
12345