Regulation of Schwann Cell Function by the Extracellular Matrix

被引:139
|
作者
Chernousov, Michael A. [2 ]
Yu, Wei-Ming [1 ]
Chen, Zu-Lin [1 ]
Carey, David J. [2 ]
Strickland, Sidney [1 ]
机构
[1] Rockefeller Univ, Lab Neurobiol & Genet, New York, NY 10065 USA
[2] Weis Ctr Res, Geisinger Clin, Danville, PA 17822 USA
关键词
peripheral nervous system; laminin; collagen; myelination;
D O I
10.1002/glia.20740
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Laminins and collagens are extracellular matrix proteins that play essential roles in peripheral nervous system development. Laminin signals regulate Schwann cell proliferation and survival as well as actin cytoskeleton dynamics, which are essential steps for radial sorting and myelination of peripheral axons by Schwann cells. Collagen and their receptors promote Schwann cell adhesion, spreading, and myelination as well as neurite outgrowth. In this article, we will review the recent advances in the studies of laminin and collagen function in Schwann cell development. (c) 2008 Wiley-Liss. Inc.
引用
收藏
页码:1498 / 1507
页数:10
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