Control of tylosin biosynthesis in Streptomyces fradiae

被引：2
|
作者：
Cundliffe, Eric [1 ]
机构：
[1] Univ Leicester, Dept Biochem, Leicester LE2 5YE, Leics, England
来源：
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2008年 / 18卷 / 09期
基金：
英国惠康基金; 英国生物技术与生命科学研究理事会;
关键词：
antibiotic production; gamma-butyrolactone; gene regulation; Streptomyces; tylosin;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Tylosin biosynthesis is controlled in cascade fashion by multiple transcriptional regulators, acting positively or negatively, in conjunction with a signalling ligand that acts as a classical inducer. The roles of regulatory gene products have been characterized by a combination of gene expression analysis and fermentation studies, using engineered strains of S. fradiae in which specific genes were inactivated or overexpressed. Among various novel features of the regulatory model, involvement of the signalling ligand is not essential for tylosin biosynthesis.
引用
收藏
页码：1485 / 1491
页数：7
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