Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase

被引：11

作者：

Marson, CM

Rioja, AS

Brooke, G

Coombes, RC

Vigushin, DM

机构：

[1] UCL, Christopher Ingold Labs, Dept Chem, London WC1H 0AJ, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Canc Med, London W12 0NN, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)00718-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cyclic acid anhydrides possessing a lipid chain have been shown to be a new class of non-peptidic inhibitors of geranylgeranyl protein-transferase type I (GGPTase-I). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：255 / 259

页数：5

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