Postsynthetic Ligand Exchange of Metal-Organic Framework for Photodynamic Therapy

被引：49

作者：

Zhao, Xueyan ^{[1
,2
]}

Zhang, Zhixiang ^{[1
]}

Cai, Xuechao ^{[1
,3
]}

Ding, Binbin ^{[1
,3
]}

Sun, Chunqiang ^{[1
]}

Liu, Guofeng ^{[1
]}

Hu, Chunling ^{[1
,3
]}

Shao, Shuai ^{[1
,2
]}

Pang, Maolin ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China

[2] Changchun Univ Sci & Technol, Changchun 130022, Jilin, Peoples R China

[3] Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2019年 / 11卷 / 08期

基金：

中国国家自然科学基金;

关键词：

metal-organic frameworks; NU-1000; postsynthetic modification; ligand exchange; photodynamic therapy; FE-SOC-MOF; SELECTIVE DETECTION; STEPWISE SYNTHESIS; DRUG-DELIVERY; NANOPARTICLES; STABILITY; FUNCTIONALIZATION; COLLOIDOSOMES; PLATFORM; AGENT;

D O I：

10.1021/acsami.9b00740

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Attributed to the large pore size and excellent stability, the metal-organic framework (MOF), NU-1000, which is formed by the coordination of Zr cluster and 1,3,6,8-tetrakis(p-benzoic acid)pyrene (H(4)TBAPy) ligand, has been widely studied in the catalysis research field; however, only a few reports about the biomedical application of NU-1000 could be found in the open literature. In this study, a functional ligand, tetrakis(4-carboxyphenyl)porphyrin (TCPP), was introduced into NU-1000 via a postsynthetic ligand exchange method and the resulting mixed ligand MOF has an excellent photodynamic effect. Finally, in vitro and in vivo assessment about the antitumor efficacy was investigated for the first time. It demonstrates the feasibility of TCPP-substituted NU-1000 to be used for photodynamic therapy and also provides an alternative approach to enrich the function of MOF for various applications via a postsynthetic method.

引用

页码：7884 / 7892

页数：9

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