Inhibition of bladder tumor growth by a cyclooxygenase-2 inhibitor and immunosuppression agents in an experimental study

被引：0

作者：

Parada, B. ^{[1
,2
]}

Reis, F. ^{[1
,6
]}

Teixeira-Lemos, E. ^{[1
]}

Sereno, J. ^{[1
]}

Pinto, A. F. ^{[1
]}

Garrido, P. ^{[1
]}

Cerejo, R. ^{[1
]}

Piloto, N. ^{[1
]}

Ferreira, L. ^{[1
]}

Cunha, M. F. ^{[3
]}

Rocha-Pereira, P. ^{[4
]}

Pinto, R. ^{[5
]}

Mota, A. ^{[2
]}

Figueiredo, A. ^{[2
]}

Teixeira, F. ^{[1
,6
]}

机构：

[1] Coimbra Univ, Inst Pharmacol & Expt Therapeut, IBILI, Fac Med, Coimbra, Portugal

[2] Coimbra Univ Hosp, Dept Urol & Renal Transplantat, Coimbra, Portugal

[3] Coimbra Univ Hosp, Pathol Unit, Coimbra, Portugal

[4] Beira Interior Univ, Res ctr Hlth Sci, Covilha, Portugal

[5] Pharm Sch Lisbon, Pharmacol & Pharmacotoxicol, Lisbon, Portugal

[6] Univ Porto, Inst Mol & Cellular Biol, Oporto, Portugal

来源：

9TH CONGRESS OF THE EUROPEAN ASSOCIATION FOR CLINICAL PHARMACOLOGY AND THERAPEUTICS - EACPT | 2009年

关键词：

bladder cancer; chemoprevention; COX-2; inhibitor; immunosuppression agents; CANCER;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the anti-carcinogenic effects of a cyclooxygenase-2 inhibitor (Celecoxib) and immunosuppression drugs - Sirolimus (SIR) and Cyclosporine (CsA) - on a rat model of bladder cancer induced by N-butyl-N(4-hydroxibutil)nitrosamine (BBN). There was a statistically significant reduction in the incidence of bladder tumors in the SIR (2 mg/kg/day) and CEL (10 mg/kg/day) groups (37.5 and 12.5%. respectively: p<0.05) vs BBN (65%). with less aggressive histological changes, together with significantly lower levels of TGF-beta 1 and a better redox status (MDA/TAS). SIR 1 mg/kg/day induced a higher nr of tumors. CsA showed no significant effect on bladder carcinogenesis. In conclusion. both Sirolimus (2mg/kg/day) and Celecoxib treatments showed chemopreventive properties for urothehal bladder tumors in rats.

引用

页码：173 / +

页数：2

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