Inhibition of bladder tumor growth by a cyclooxygenase-2 inhibitor and immunosuppression agents in an experimental study

被引：0
|
作者：
Parada, B. [1 ,2 ]
Reis, F. [1 ,6 ]
Teixeira-Lemos, E. [1 ]
Sereno, J. [1 ]
Pinto, A. F. [1 ]
Garrido, P. [1 ]
Cerejo, R. [1 ]
Piloto, N. [1 ]
Ferreira, L. [1 ]
Cunha, M. F. [3 ]
Rocha-Pereira, P. [4 ]
Pinto, R. [5 ]
Mota, A. [2 ]
Figueiredo, A. [2 ]
Teixeira, F. [1 ,6 ]
机构：
[1] Coimbra Univ, Inst Pharmacol & Expt Therapeut, IBILI, Fac Med, Coimbra, Portugal
[2] Coimbra Univ Hosp, Dept Urol & Renal Transplantat, Coimbra, Portugal
[3] Coimbra Univ Hosp, Pathol Unit, Coimbra, Portugal
[4] Beira Interior Univ, Res ctr Hlth Sci, Covilha, Portugal
[5] Pharm Sch Lisbon, Pharmacol & Pharmacotoxicol, Lisbon, Portugal
[6] Univ Porto, Inst Mol & Cellular Biol, Oporto, Portugal
来源：
9TH CONGRESS OF THE EUROPEAN ASSOCIATION FOR CLINICAL PHARMACOLOGY AND THERAPEUTICS - EACPT | 2009年
关键词：
bladder cancer; chemoprevention; COX-2; inhibitor; immunosuppression agents; CANCER;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We investigated the anti-carcinogenic effects of a cyclooxygenase-2 inhibitor (Celecoxib) and immunosuppression drugs - Sirolimus (SIR) and Cyclosporine (CsA) - on a rat model of bladder cancer induced by N-butyl-N(4-hydroxibutil)nitrosamine (BBN). There was a statistically significant reduction in the incidence of bladder tumors in the SIR (2 mg/kg/day) and CEL (10 mg/kg/day) groups (37.5 and 12.5%. respectively: p<0.05) vs BBN (65%). with less aggressive histological changes, together with significantly lower levels of TGF-beta 1 and a better redox status (MDA/TAS). SIR 1 mg/kg/day induced a higher nr of tumors. CsA showed no significant effect on bladder carcinogenesis. In conclusion. both Sirolimus (2mg/kg/day) and Celecoxib treatments showed chemopreventive properties for urothehal bladder tumors in rats.
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页码：173 / +
页数：2
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