A traceless linker approach to the solid phase synthesis of substituted guanidines utilizing a novel acyl isothiocyanate resin

被引：43
|
作者：
Wilson, LJ [1 ]
Klopfenstein, SR [1 ]
Li, M [1 ]
机构：
[1] Procter & Gamble Pharmaceut, Hlth Care Res Ctr, Mason, OH 45040 USA
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 21期
关键词：
solid phase synthesis; guanidines; EDC; combinatorial chemistry; isothiocyanate;
D O I：
10.1016/S0040-4039(99)00663-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Solid phase synthesis of a series of substituted guanidines based on a novel acyl isothiocyanate resin is presented. This method provides both mono and disubstituted guanidines with a variety of sterically demanding and/or electron withdrawing substituents in good purities and yields. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3999 / 4002
页数：4
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