1,4-Asymmetric induction in the titanium-mediated aldol reactions of α-benzyloxy methyl ketones

被引：16

作者：

Pellicena, Miquel ^{[1
]}

Solsona, Joan G. ^{[1
]}

Romea, Pedro ^{[1
]}

Urpi, Felix ^{[1
]}

机构：

[1] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Catalonia, Spain

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 36期

关键词：

stereoselective reactions; acetate aldol reactions; titanium enolates; chiral ketones;

D O I：

10.1016/j.tetlet.2008.06.120

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Good levels of 1,4-anti asymmetric induction are obtained in the TiCl(3)(i-PrO)-mediated aldol reaction of alpha-benzyloxy methyl ketones with achiral alclehydes. Such methodology represents a new approach to the substrate-controlled acetate aldol reaction, which can be Useful to design more efficient synthesis. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：5265 / 5267

页数：3

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