Culcitiolides E-J, Six New Eremophilane-Type Sesquiterpene Derivatives from Senecio culcitioides

被引：9

作者：

Mitsui, Taichi ^{[1
]}

Hayashi, Ken-ichiro ^{[1
]}

Kawai, Mikiko ^{[2
]}

Kido, Masahiro ^{[2
]}

Tani, Hiroyuki ^{[2
]}

Takaoka, Daisuke ^{[3
]}

Matsuura, Nobuyasu ^{[1
]}

Nozaki, Hiroshi ^{[1
]}

机构：

[1] Okayama Univ Sci, Fac Sci, Dept Biol Chem, Okayama 7000005, Japan

[2] Ehime Univ, Grad Sch Sci & Engn, Matsuyama, Ehime 7908577, Japan

[3] Ehime Univ, Fac Gen Educ, Dept Chem, Matsuyama, Ehime 7908577, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2013年 / 61卷 / 08期

关键词：

Senecio culcitioides; eremophilane; culcitiolide; nuclear factor kappa B; PHOTOSENSITIZED OXYGENATION; ISOMERIC HYDROPEROXIDES; KAPPA-B; LACTONES; FURANOEREMOPHILANES; TRANSFORMATIONS;

D O I：

10.1248/cpb.c13-00243

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Culcitiolides E-J (1-6), six new eremophilane-type sesquiterpenes, were isolated from the stem of Senecio culcitioides SCH. BIP. (Asteraceae). The structures were determined by detailed NMR spectral analysis. The inhibitory activities of these compounds against nuclear factor kappa B (NF-kappa B)-dependent gene expression were assessed. Culcitiolides E, H, and I potently inhibited NF-kappa B-induced gene expression at 20 mu M.

引用

页码：816 / 822

页数：7

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