Culcitiolides E-J, Six New Eremophilane-Type Sesquiterpene Derivatives from Senecio culcitioides

被引：9

作者：

Mitsui, Taichi ^{[1
]}

Hayashi, Ken-ichiro ^{[1
]}

Kawai, Mikiko ^{[2
]}

Kido, Masahiro ^{[2
]}

Tani, Hiroyuki ^{[2
]}

Takaoka, Daisuke ^{[3
]}

Matsuura, Nobuyasu ^{[1
]}

Nozaki, Hiroshi ^{[1
]}

机构：

[1] Okayama Univ Sci, Fac Sci, Dept Biol Chem, Okayama 7000005, Japan

[2] Ehime Univ, Grad Sch Sci & Engn, Matsuyama, Ehime 7908577, Japan

[3] Ehime Univ, Fac Gen Educ, Dept Chem, Matsuyama, Ehime 7908577, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2013年 / 61卷 / 08期

关键词：

Senecio culcitioides; eremophilane; culcitiolide; nuclear factor kappa B; PHOTOSENSITIZED OXYGENATION; ISOMERIC HYDROPEROXIDES; KAPPA-B; LACTONES; FURANOEREMOPHILANES; TRANSFORMATIONS;

D O I：

10.1248/cpb.c13-00243

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Culcitiolides E-J (1-6), six new eremophilane-type sesquiterpenes, were isolated from the stem of Senecio culcitioides SCH. BIP. (Asteraceae). The structures were determined by detailed NMR spectral analysis. The inhibitory activities of these compounds against nuclear factor kappa B (NF-kappa B)-dependent gene expression were assessed. Culcitiolides E, H, and I potently inhibited NF-kappa B-induced gene expression at 20 mu M.

引用

页码：816 / 822

页数：7

共 50 条

[1] Culcitiolides A-D, Four New Eremophilane-Type Sesquiterpene Derivatives from Senecio culcitioides
Nozaki, Hiroshi
Hayashi, Ken-ichiro
Kawai, Mikiko
Mitsui, Taichi
Kido, Masahiro
Tani, Hiroyuki
Takaoka, Daisuke
Uno, Hidemitsu
Ohira, Susumu
Kuboki, Atsuto
Matsuura, Nobuyasu
NATURAL PRODUCT COMMUNICATIONS, 2012, 7 (04) : 427 - 430
[2] Eremophilane-type sesquiterpene derivatives from Senecio aegyptius var. discoideus
Mohamedt, AEH
Ahmed, AA
JOURNAL OF NATURAL PRODUCTS, 2005, 68 (03): : 439 - 442
[3] Eremophilane-Type Sesquiterpene Derivatives from Ligularia hodgsonii
Li, Wen-Xian
Lei, Ming
Fei, Dong-Qing
Gao, Kun
PLANTA MEDICA, 2009, 75 (06) : 635 - 640
[4] Eremophilane-type sesquiterpene derivatives from the roots of Ligularia lapathifolia
Fei, Dong-Qing
Li, Shi-Gang
Liu, Chun-Mei
Wu, Gang
Gao, Kun
JOURNAL OF NATURAL PRODUCTS, 2007, 70 (02): : 241 - 245
[5] A new eremophilane-type sesquiterpene from Ligularia virgaurea
Fei, Dong Qing
Zhang, Zhan Xin
CHINESE CHEMICAL LETTERS, 2009, 20 (08) : 949 - 951
[6] A new eremophilane-type sesquiterpene from Ligularia virgaurea
Dong Qing Fei
Chinese Chemical Letters, 2009, 20 (08) : 949 - 951
[7] Eremophilane-type Sesquiterpenes from Senecio nemorensis
Fei, Dong-Qing
Zhang, Zhan-Xin
Chen, Jian-Jun
Gao, Kun
PLANTA MEDICA, 2007, 73 (12) : 1292 - 1297
[8] Todasinoid A, a New Eremophilane-type Sesquiterpene from the Plant Toddalia asiatica
Cai, Lijing
Zhang, Mengying
He, Jie
Lin, Tingting
RECORDS OF NATURAL PRODUCTS, 2023, 17 (02) : 382 - 387
[9] A new eremophilane sesquiterpene from Senecio nemorensis
Meng, Fanjun
Xie, Weidong
Row, Kyungho
JOURNAL OF CHEMICAL RESEARCH, 2008, (07) : 376 - 377
[10] A new eremophilane-type sesquiterpene from the phytopatogen fungus Lasiodiplodia theobromae (Sphaeropsidaceae)
Nunes, Fatima M.
de Oliveira, Maria da Conceicao F.
Arriaga, Angela M. C.
Lemos, Telma L. G.
Andrade-Neto, Manoel
de Mattos, Marcos C.
Mafezoli, Jair
Viana, Francisco M. P.
Ferreira, Viviane M.
Rodrigues-Filho, Edson
Ferreira, Antonio G.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2008, 19 (03) : 478 - 482

← 1 2 3 4 5 →