Relationship between the expressions of PD-L1 and tumour-associated fibroblasts in gastric cancer

被引：23
|
作者：
Mu, Linsong [1 ,2 ]
Yu, Wentao [2 ]
Su, Hailong [2 ]
Lin, Yang [2 ]
Sui, Wu [2 ]
Yu, Xiang [2 ]
Qin, Chengkun [3 ]
机构：
[1] Shandong Univ, Shandong Prov Hosp, Dept Gen Surg, Jinan 250021, Shandong, Peoples R China
[2] Qingdao Univ, Affiliated Yantai Yuhuangding Hosp, Dept Gen Surg, Yantai 264000, Peoples R China
[3] Shandong Univ, Shandong Prov Hosp, Dept Hepatol Surg, 324 By 5, Jinan 250021, Shandong, Peoples R China
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2019年 / 47卷 / 01期
关键词：
Gastric cancer; TAF; PD-1/PD-L1; immune escape; CELL LUNG-CANCER; STROMAL FIBROBLASTS; GROWTH; GENES;
D O I：
10.1080/21691401.2019.1573741
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Previous studies have focused on the changes of tumour cells in immune escape, and less is known about the effect of tumour microenvironment (TME) on immune escape. Tumour-associated fibroblasts (TAF) is an important part of the TME and has special physiological and biochemical characteristics, but the specific mechanism has not been clarified. In order to investigate the effect of TAF on the expression of PD-L1 in gastric cancer cells, gastric cancer cell lines MNK45, SGC7901 were non-contact co-culturing with TAF 1, 3 and 7 d via transwell. PD-L1 mRNA and protein expression were detected using qRT-PCR and FCM. Then, 95 cases of gastric cancer tissues were selected and evaluated PD-L1 and TAF expressions by immunohistochemical examination. The results showed that the mRNA and protein expression of PD-L1 in the experiment group were significantly higher than that in the control group. PD-L1 expression was associated with massive lymphocyte infiltration, diffuse/mixed histology and intratumoral TAFs in gastric cancers. In conclusion, TAFs promoted the growth in gastric cancer cell lines by increased the PD-L1 expression.
引用
收藏
页码：1036 / 1042
页数：7
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