Iron-Sulfur Clusters: A Key Factor of Regulated Cell Death in Cancer

被引：10

作者：

Zhang, Mengning ^{[1
]}

Liu, Zhijun ^{[2
]}

Le, Yifei ^{[2
]}

Gu, Zhenqi ^{[1
]}

Zhao, Hong ^{[1
,3
]}

机构：

[1] Zhejiang Chinese Med Univ, Sch Clin Med 1, Hangzhou, Peoples R China

[2] Zhejiang Chinese Med Univ, Sch Life Sci, Hangzhou, Peoples R China

[3] Zhejiang Chinese Med Univ, Zhejiang Prov Hosp Tradit Chinese Med, Affiliated Hosp 1, Hangzhou, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2022年 / 2022卷

关键词：

FE-S CLUSTER; HUMAN FERROCHELATASE; FRIEDREICH ATAXIA; FERROPTOSIS; BIOGENESIS; APOPTOSIS; METABOLISM; PROLIFERATION; DISULFIRAM; ACTIVATION;

D O I：

10.1155/2022/7449941

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Iron-sulfur clusters are ancient cofactors that play crucial roles in myriad cellular functions. Recent studies have shown that iron-sulfur clusters are closely related to the mechanisms of multiple cell death modalities. In addition, numerous previous studies have demonstrated that iron-sulfur clusters play an important role in the development and treatment of cancer. This review first summarizes the close association of iron-sulfur clusters with cell death modalities such as ferroptosis, cuprotosis, PANoptosis, and apoptosis and their potential role in cancer activation and drug resistance. This review hopes to generate new cancer therapy ideas and overcome drug resistance by modulating iron-sulfur clusters.

引用

页数：15

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