MLN4924, an Investigational NEDD8-Activating Enzyme Inhibitor, Induces Differentiation in Acute Myelogenous Leukemia Cell Lines

被引:0
|
作者
Thomas, M. P. [1 ]
Milhollen, M. A. [1 ]
Naryanan, U. [1 ]
McDonald, A. [1 ]
Fleming, M. [2 ]
Amidon, B. [1 ]
Manfredi, M. [1 ]
Smith, P. G. [3 ]
Berger, A. J. [1 ]
机构
[1] Millennium Takeda Oncol Co, Discovery Oncol, Cambridge, MA USA
[2] Childrens Hosp, Boston, MA 02115 USA
[3] H3 Biomed, Drug Discovery Biol, Cambridge, MA USA
关键词
D O I
10.1016/S0959-8049(12)72084-1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
286
引用
收藏
页码:88 / 88
页数:1
相关论文
共 50 条
  • [31] Azacitidine/Decitabine Synergism with the NEDD8-Activating Enzyme Inhibitor MLN4924 in Pre-Clinical AML Models
    Smith, Peter G.
    Traore, Tary
    Grossman, Steve
    Narayanan, Usha
    Carew, Jennifer S.
    Lublinksky, Anya
    Kuranda, Michael
    Milhollen, Michael
    BLOOD, 2011, 118 (21) : 267 - 267
  • [32] Suppression of mTOR Signaling Attenuates Apoptotic Effects Induced By the NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Acute Myeloid Leukemia Cells
    Guo, Naxin
    Nemer, Mary
    Sivagnanalingam, Subanky
    Azadniv, Mitra
    Mendler, Jason H.
    Becker, Michael W.
    Liesveld, Jane L.
    BLOOD, 2017, 130
  • [33] Preclinical evaluation of MLN4924, the first small molecule inhibitor of NEDD8-activating enzyme (INAE) for the treatment of cancer
    Soucy, Teresa
    Smith, Peter
    Milhollen, Michael
    Berger, Allison
    Davis, Barbara
    Yang, Hua
    Lublinsky, Anya
    Zhang, Julie
    Traore, Tary
    Narayanan, Usha
    Yu, Jie
    Garnsey, James
    Gavin, James
    Weatherhead, Gabriel
    Cullis, Courtney
    Olhava, Edward
    Vyskocil, Stepan
    Rolfe, Mark
    Langston, Steven
    MOLECULAR CANCER THERAPEUTICS, 2007, 6 (12) : 3521S - 3521S
  • [34] Clinical pharmacodynamic assay development for the first small molecule inhibitor of Nedd8-activating enzyme (NAE), MLN4924
    Garnsey, James Joseph
    Walker, Russell M.
    Pickard, Michael D.
    Traore, Tary
    Thomas, Michael
    Zhang, Julie
    Xia, Cindy
    Zhang, Ji
    Mulligan, George
    Smith, Peter G.
    Berger, Allison J.
    MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12)
  • [35] Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma
    Shah, Jatin J.
    Jakubowiak, Andrzej J.
    O'Connor, Owen A.
    Orlowski, Robert Z.
    Harvey, R. Donald
    Smith, Mitchell R.
    Lebovic, Daniel
    Diefenbach, Catherine
    Kelly, Kevin
    Hua, Zhaowei
    Berger, Allison J.
    Mulligan, George
    Faessel, Helene M.
    Tirrell, Stephen
    Dezube, Bruce J.
    Lonial, Sagar
    CLINICAL CANCER RESEARCH, 2016, 22 (01) : 34 - 43
  • [36] Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors
    Sarantopoulos, John
    Shapiro, Geoffrey I.
    Cohen, Roger B.
    Clark, Jeffrey W.
    Kauh, John S.
    Weiss, Glen J.
    Cleary, James M.
    Mahalingam, Devalingam
    Pickard, Michael D.
    Faessel, Helene M.
    Berger, Allison J.
    Burke, Kristine
    Mulligan, George
    Dezube, Bruce J.
    Harvey, R. Donald
    CLINICAL CANCER RESEARCH, 2016, 22 (04) : 847 - 857
  • [37] THE FIRST-IN-CLASS SMALL MOLECULE INHIBITOR OF NEDD8-ACTIVATING ENZYME (NAE), MLN4924, INDUCES STABLE DISEASE REGRESSION IN PRECLINICAL MODELS OF ACUTE MYELOID LEUKEMIA (AML)
    Carew, J.
    Swords, R.
    Kelly, K.
    Smith, P.
    Garnsey, J.
    Mahalingam, D.
    Medina, E.
    O'Dwyer, M.
    Oberheu, K.
    Nawrocki, S.
    Giles, F.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 : 183 - 183
  • [38] The Novel, Investigational NEDD8-Activating Enzyme Inhibitor MLN4924 In Adult Patients with Acute Myeloid Leukemia (AML) or High-Grade Myelodysplastic Syndromes (MDS): A Phase 1 Study
    Swords, Ronan T.
    Erba, Harry P.
    DeAngelo, Daniel J.
    Smith, Peter G.
    Pickard, Michael D.
    Dezube, Bruce J.
    Giles, Francis J.
    Medeiros, Bruno C.
    BLOOD, 2010, 116 (21) : 288 - 288
  • [39] Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells
    Wang, Yanchun
    Luo, Zhongguang
    Pan, Yongfu
    Wang, Weige
    Zhou, Xiaoyan
    Jeong, Lak Shin
    Chu, Yiwei
    Liu, Jie
    Jia, Lijun
    CANCER BIOLOGY & THERAPY, 2015, 16 (03) : 420 - 429
  • [40] Mutations in UBA3 Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Human Leukemic Cells
    Xu, G. Wei
    Toth, Julia I.
    da Silva, Sara R.
    Paiva, Stacey-Lynn
    Lukkarila, Julie L.
    Hurren, Rose
    Maclean, Neil
    Sukhai, Mahadeo A.
    Bhattacharjee, Rabindra N.
    Goard, Carolyn A.
    Gunning, Patrick T.
    Dhe-Paganon, Sirano
    Petroski, Matthew D.
    Schimmer, Aaron D.
    PLOS ONE, 2014, 9 (04):