Galaxy HiCExplorer 3: a web server for reproducible Hi-C, capture Hi-C and single-cell Hi-C data analysis, quality control and visualization

被引：84

作者：

Wolff, Joachim ^{[1
]}

Rabbani, Leily ^{[2
]}

Gilsbach, Ralf ^{[3
,4
,5
]}

Richard, Gautier ^{[6
]}

Manke, Thomas ^{[2
]}

Backofen, Rolf ^{[1
,7
,8
]}

Gruening, Bjoern A. ^{[1
]}

机构：

[1] Univ Freiburg, Dept Comp Sci, Bioinformat Grp, Georges Kohler Allee 106, D-79110 Freiburg, Germany

[2] Max Planck Inst Immunobiol & Epigenet, Stubeweg 51, D-79108 Freiburg, Germany

[3] Goethe Univ, Inst Cardiovasc Physiol, Frankfurt, Germany

[4] German Ctr Cardiovasc Res DZHK, Partner Site RheinMain, Frankfurt, Germany

[5] Univ Freiburg, Fac Med, Inst Expt & Clin Pharmacol & Toxicol, Freiburg, Germany

[6] Univ Rennes, INRAE, Agrocampus Ouest, IGEPP, F-35650 Le Rheu, France

[7] Univ Freiburg, Signalling Res Ctr BIOSS, Schanzlestr 18, D-79104 Freiburg, Germany

[8] Univ Freiburg, CIBSS, Schanzlestr 18, D-79104 Freiburg, Germany

来源：

NUCLEIC ACIDS RESEARCH | 2020年 / 48卷 / W1期

关键词：

CHROMOSOME CONFORMATION CAPTURE; ORGANIZATION; PRINCIPLES; DOMAINS; GENOME;

D O I：

10.1093/nar/gkaa220

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Galaxy HiCExplorer provides a web service at https://hicexplorer.usegalaxy.eu. It enables the integrative analysis of chromosome conformation by providing tools and computational resources to pre-process, analyse and visualize Hi-C, Capture Hi-C (cHi-C) and single-cell Hi-C (scHi-C) data. Since the last publication, Galaxy HiCExplorer has been expanded considerably with new tools to facilitate the analysis of cHi-C and to provide an in-depth analysis of Hi-C data. Moreover, it supports the analysis of scHi-C data by offering a broad range of tools. With the help of the standard graphical user interface of Galaxy, presented workflows, extensive documentation and tutorials, novices as well as Hi-C experts are supported in their Hi-C data analysis with Galaxy HiCExplorer.

引用

页码：W177 / W184

页数：8

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