Synthesis and Evaluation of Some New Thiazolidin-4-One Derivatives as Potential Antimicrobial Agents

被引：3
|
作者：
Baviskar, B. A. [1 ,2 ]
Khadabadi, S. S. [3 ]
Deore, S. L. [2 ]
机构：
[1] Govt Coll Pharm, Dept Pharmaceut Chem, Amravati 444604, Maharashtra, India
[2] Govt Coll Pharm, Dept Pharmacognosy & Phytochem, Amravati 444604, Maharashtra, India
[3] Govt Coll Pharm, Dept Pharmacognosy & Phytochem, Aurangabad 431005, Maharashtra, India
来源：
JOURNAL OF CHEMISTRY | 2013年 / 2013卷
关键词：
AZETIDINONE COMPOUNDS; SCHIFF-BASE; ANTIBACTERIAL; THIAZOLE;
D O I：
10.1155/2013/656271
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new series of N-{4-methyl-5-[4-(4-oxo-2-phenyl(1,3-thiazolidin-3-yl)]-5-sulfanyl(1,2,4-triazol-3-yl)-1,3-thiazol-2-yl]-acetamide (7a-1) was synthesized in order to determine their antimicrobial activity and feasible structure-activity relationships. The compounds were synthesized in good yield and the structures of all newly synthesized compounds were established on the basis of their IR, 1HNMR, and elemental analysis. The synthesized compounds were tested in vitro antibacterial activity against staphylococcus acureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi and antifungal activity against Aspergillus niger, Candida albicans by measuring the zone of inhibition in mm.
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页数：6
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