Assembly of Gene Expression Networks Based on a Breast Cancer Signature

被引：0
|
作者：
Ntellis, Dimitrios Apostolos Chalepakis [1 ]
Bei, Ekaterini S. [1 ]
Kafetzopoulos, Dimitrios [2 ]
Zervakis, Michalis [1 ]
机构：
[1] Tech Univ Crete, Sch Elect & Comp Engn, Khania, Greece
[2] FORTH, Inst Mol Biol & Biotechnol, Iraklion, Greece
来源：
BIOINFORMATICS AND BIOMEDICAL ENGINEERING, IWBBIO 2017, PT II | 2017年 / 10209卷
关键词：
Gene expression networks; Bayesian networks; Protein-Protein interactions; Breast cancer markers; K2; ALGORITHM; IDENTIFICATION; CELLS;
D O I：
10.1007/978-3-319-56154-7_7
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The aim of this paper is to provide a snapshot of functional networks with central nodes (hubs) relying on the behavior of genes linked to a specific interaction network. Utilizing a 'breast cancer signature', a Bayesian approach is applied for the construction of gene interaction networks from different populations. We demonstrate that the hub genes of the differentiating network between cancer and control states can be regarded as potential markers for breast cancer. Furthermore, the differentiating subnetworks can be informative of the phenotype and provide new knowledge about the functional interactions and molecular pathways involved in breast cancer.
引用
收藏
页码：62 / 73
页数：12
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