A role of androgen receptor protein in cell growth of an androgen-independent prostate cancer cell line

被引：10

作者：

Furutani, T

Takeyama, KI

Koutoku, H

Ito, S

Taniguchi, N

Suzuki, E

Kudoh, M

Shibasaki, M

Shikama, H

Kato, S

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo 1130032, Japan

[2] Astellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, Japan

[3] Japan Sci & Technol, ERATO, Kawaguchi, Saitama 3320012, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2005年 / 69卷 / 11期

关键词：

prostate cancer; androgen receptor; androgen receptor antagonist;

D O I：

10.1271/bbb.69.2236

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prostate cancer, which develops due to androgen and is initially responsive to androgen deprivation therapy, often comes to acquire androgen deprivation therapy resistance in short order. We investigated the role of androgen receptor (AR) protein in an androgen-independent prostate cancer cell line using AR ligands and AR siRNA. Although the androgen-independent cell line scarcely responded to AR ligands, their growth was attenuated by ablation of AR protein by siRNA.

引用

页码：2236 / 2239

页数：4

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