Inflammation and preeclampsia

No individual can claim credit for all the advances made during his lifetime. However, certain individuals have a far greater influence than others. Prof. Christopher Redman has had a huge role to play in increasing the understanding of the aetiology, pathology, progression and management of preeclampsia. The work he did personally, led in others and stimulated in colleagues, both friend and foe, has helped to progress preeclampsia from a disease that came from nowhere to one that is more understood and safely managed. In this paper, it is the work in immunology that will be concentrated on in a chronological way but this will be linked to other relevant research and clinical practice. The understanding that preeclampsia is a two-stage disease starting in the placenta and progressing systemically has led to greater understanding as well as more questions. The universal role of immunology first as an acceptor within the placental bed then as a disease driver in the systemic circulation emphasises the good and the bad in physiological systems. Prof. Redman has been present in all these areas of discovery and enlightenment as will be described. (C) 2010 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.