The effect of Bulgarian propolis against Trypanosoma cruzi and during its interaction with host cells

被引：38

作者：

Dantas, AP

Salomao, K

Barbosa, HS

De Castro, SL

机构：

[1] Fiocruz MS, Inst Oswaldo Cruz, Lab Biol Celular, BR-21040900 Rio De Janeiro, Brazil

[2] Fiocruz MS, Inst Oswaldo Cruz, Lab Biol Estrutural, Dept Ultraestrutura & Biol Celular, BR-21040900 Rio De Janeiro, Brazil

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2006年 / 101卷 / 02期

关键词：

propolis; natural products; Trypanosoma cruzi; Chagas disease;

D O I：

10.1590/S0074-02762006000200013

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Propolis has shown activity against pathogenic microorganisms that cause diseases in humans and animals. The ethanol (Et-Blg) and acetone (Ket-Blg) extracts from a Bulgarian propolis, with known chemical compositions, presented similar activity against tissue culture-derived amastigotes. The treatment of Trypanosoma cruzi-infected skeletal muscle cells with Et-Blg led to a decrease of infection and of the intracellular proliferation of amastigotes, while damage to the host cell was observed only at concentration 12.5 times higher than those affecting the parasite. Ultrastructural analysis of the effect of both extracts in epimastigotes revealed that the main targets were the mitochondrion and reservosomes. Et-Blg also affected the mitochondrion-kinetoplast complex in trypomastigotes, offering a potential target for chemotherapeutic agents.

引用

页码：207 / 211

页数：5

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