Assessment of Comparative Toxicity of Nano- and Microparticles Magnetite

被引：0

作者：

Katsnelson, B. A. ^{[1
]}

Privalova, L. I. ^{[1
]}

Degtyareva, T. D. ^{[1
]}

Kuzmin, S. V. ^{[1
]}

Sutunkova, M. P. ^{[1
]}

Minigalieva, I. A. ^{[1
]}

Kireyeva, E. P. ^{[1
]}

Khodos, M. Y. ^{[2
]}

Shur, V. Y. ^{[3
]}

Nikolaeva, E. V. ^{[3
]}

Valamina, I. E. ^{[4
]}

Tulakina, L. G. ^{[5
]}

Pichugova, S. V. ^{[5
]}

Beykin, J. B. ^{[5
]}

机构：

[1] Med Res Ctr Prophylaxis & Hlth Protect Ind Worker, Ekaterinburg, Russia

[2] Sci Prod & Innovat Assoc Ltd, Ekaterinburg, Russia

[3] Ural State Univ, Ekaterinburg, Russia

[4] Ural State Med Acad, Ekaterinburg, Russia

[5] Mtmicipal Agcy, Clin & Diagnost Ctr, Ekaterinburg, Russia

来源：

NANOTECHNOLOGY 2011: BIO SENSORS, INSTRUMENTS, MEDICAL, ENVIRONMENT AND ENERGY, NSTI-NANOTECH 2011, VOL 3 | 2011年

关键词：

nanoparticles; magnetite; subchronic toxicity; CHRONIC INHALATION EXPOSURE; MULTICOMPARTMENTAL MODEL; QUARTZ DUST; CYTOTOXICITY;

D O I：

暂无

中图分类号：

TE [石油、天然气工业]; TK [能源与动力工程];

学科分类号：

0807 ; 0820 ;

摘要：

The key mechanism of pulmonary region's clearance from deposited particles is recruitment of phagocytizing cells on its free surface. Phagocytosis hinders penetration of these particles into pulmonary interstices and thus promotes mucociliary clearancetil. The alveolar macrophage (AM) is the main cell effector of phagocytosis-mediated pulmonary clearance, the neutrophile leukocyte (NL) being the most important auxiliary one. NLs recruitment is controlled by the number of destroyed AMs. That's why the intensity of NLs recruitment toward deposited particles depends quantitatively on their cytotoxicity for macrophages([1-5]). Thus NL/AM ratio may be used as a criterion of comparative cytotoxicity of particles. Another nano-toxicological problem of theoretical and practical importance is the size-dependence of the comparative resorptive toxicity of particles of substances that are deemed innocuous in bulk.

引用

页码：537 / 540

页数：4

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