The PPARγ-FGF1 axis: an unexpected mediator of adipose tissue homeostasis

被引：15

作者：

Sun, Kai ^{[1
]}

Scherer, Philipp E. ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Touchstone Diabet Ctr, Dept Internal Med, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Cell Biol, Dallas, TX 75390 USA

来源：

CELL RESEARCH | 2012年 / 22卷 / 10期

关键词：

GROWTH-FACTOR; OBESITY; FIBROBLAST-GROWTH-FACTOR-1; HYPOXIA; BIOLOGY; FAT;

D O I：

10.1038/cr.2012.94

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Adipose tissue remodeling is a dynamic process during nutritional fluctuation that plays critical roles in metabolic homeostasis and insulin sensitivity. The process is highly regulated by many factors, including adipokines and cytokines that are locally released within fat pads. In a recent study published in Nature, Jonker and colleagues identified FGF1 as an important mediator that is selectively induced in fat cells by high-fat diet feeding and established the PPAR gamma-FGF1 axis as a critical pathway that regulates adipose tissue remodeling and ultimately systemic metabolic homeostasis.

引用

页码：1416 / 1418

页数：3

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