The PPARγ-FGF1 axis: an unexpected mediator of adipose tissue homeostasis

被引：15

作者：

Sun, Kai ^{[1
]}

Scherer, Philipp E. ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Touchstone Diabet Ctr, Dept Internal Med, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Cell Biol, Dallas, TX 75390 USA

来源：

CELL RESEARCH | 2012年 / 22卷 / 10期

关键词：

GROWTH-FACTOR; OBESITY; FIBROBLAST-GROWTH-FACTOR-1; HYPOXIA; BIOLOGY; FAT;

D O I：

10.1038/cr.2012.94

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Adipose tissue remodeling is a dynamic process during nutritional fluctuation that plays critical roles in metabolic homeostasis and insulin sensitivity. The process is highly regulated by many factors, including adipokines and cytokines that are locally released within fat pads. In a recent study published in Nature, Jonker and colleagues identified FGF1 as an important mediator that is selectively induced in fat cells by high-fat diet feeding and established the PPAR gamma-FGF1 axis as a critical pathway that regulates adipose tissue remodeling and ultimately systemic metabolic homeostasis.

引用

下载

页码：1416 / 1418

页数：3

共 50 条

[1] The PPARγ-FGF1 axis: an unexpected mediator of adipose tissue homeostasis
Kai Sun
Philipp E Scherer
Cell Research, 2012, 22 : 1416 - 1418
[2] A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
Johan W. Jonker
Jae Myoung Suh
Annette R. Atkins
Maryam Ahmadian
Pingping Li
Jamie Whyte
Mingxiao He
Henry Juguilon
Yun-Qiang Yin
Colin T. Phillips
Ruth T. Yu
Jerrold M. Olefsky
Robert R. Henry
Michael Downes
Ronald M. Evans
Nature, 2012, 485 : 391 - 394
[3] A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
Jonker, Johan W.
Suh, Jae Myoung
Atkins, Annette R.
Ahmadian, Maryam
Li, Pingping
Whyte, Jamie
He, Mingxiao
Juguilon, Henry
Yin, Yun-Qiang
Phillips, Colin T.
Yu, Ruth T.
Olefsky, Jerrold M.
Henry, Robert R.
Downes, Michael
Evans, Ronald M.
NATURE, 2012, 485 (7398) : 391 - U143
[4] PS21 - 100. A PPAR -FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
Johan W. Jonker
Jay-Myoung Suh
Annette R. Atkins
Maryam Ahmadian
Pingping Li
Jamie Whyte
Mingxiao He
Henry Juguilon
Yun-Qiang Yin
Colin T. Phillips
Ruth T. Yu
Jerrold M. Olefsky
Robert R. Henry
Michael Downes
Ronald M. Evans
Nederlands Tijdschrift voor Diabetologie, 2012, 10 (3) : 170 - 170
[5] FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPAR and PPAR Agonists
Li, Xiaodong
Stanislaus, Shanaka
Asuncion, Frank
Niu, Qing-Tian
Chinookoswong, Narumol
Villasenor, Kelly
Wang, Jin
Wong, Philip
Boyce, Rogely
Dwyer, Denise
Han, Chun-Ya
Chen, Michelle M.
Liu, Benxian
Stolina, Marina
Ke, Hua Zhu
Ominsky, Michael S.
Veniant, Murielle M.
Xu, Jing
JOURNAL OF BONE AND MINERAL RESEARCH, 2017, 32 (04) : 834 - 845
[6] Hypothalamic FGF1 Regulates Systemic Glucose and Energy Homeostasis
Shin, Emi
Suh, Jae Myoung
DIABETES, 2023, 72
[7] FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis
Rachel J. Perry
Sangwon Lee
Lie Ma
Dongyan Zhang
Joseph Schlessinger
Gerald I. Shulman
Nature Communications, 6
[8] Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPARα-FGF21 Axis
Athinarayanan, Shaminie
Fan, Yang-Yi
Wang, Xiaokun
Callaway, Evelyn
Cai, Defeng
Chalasani, Naga
Chapkin, Robert S.
Liu, Wanqing
HEPATOLOGY COMMUNICATIONS, 2021, 5 (03) : 461 - 477
[9] FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis
Perry, Rachel J.
Lee, Sangwon
Ma, Lie
Zhang, Dongyan
Schlessinger, Joseph
Shulman, Gerald I.
NATURE COMMUNICATIONS, 2015, 6
[10] Unraveling the Heparan Sulfate Proteoglycan FGF1 Axis in Organismal Energy Metabolism
Pessentheiner, Ariane
Yu, Chung-Jui
Maciej-Hulme, Marissa
Thomas, Nathan
Liu, Shihao
Trieger, Greg
Downes, Michael
Evans, Ronald M.
Godula, Kamil
Gordts, Philip
GLYCOBIOLOGY, 2023, 33 (11) : 990 - 990

← 1 2 3 4 5 →