Harnessing genomics and genome biology to understand malaria biology

被引：76

作者：

Volkman, Sarah K. ^{[1
,2
,3
]}

Neafsey, Daniel E. ^{[2
]}

Schaffner, Stephen F. ^{[2
]}

Park, Daniel J. ^{[2
,4
]}

Wirth, Dyann F. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[2] Broad Inst, Cambridge, MA 02142 USA

[3] Simmons Coll, Sch Nursing & Hlth Sci, Boston, MA 02115 USA

[4] Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA

来源：

NATURE REVIEWS GENETICS | 2012年 / 13卷 / 05期

基金：

美国国家卫生研究院;

关键词：

CELL-CYCLE PROGRESSION; PLASMODIUM-FALCIPARUM; DRUG-RESISTANCE; POPULATION-STRUCTURE; NATURAL-SELECTION; ARTEMISININ RESISTANCE; TRANSCRIPTION FACTORS; ANTIGENIC VARIATION; POSITIVE SELECTION; QUININE RESISTANCE;

D O I：

10.1038/nrg3187

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Malaria is an important human disease and is the target of a global eradication campaign. New technological and informatics advancements in population genomics are being leveraged to identify genetic loci under selection in the malaria parasite and to find variants that are associated with key clinical phenotypes, such as drug resistance. This article provides a timely Review of how population-genetics-based strategies are being applied to Plasmodium falciparum both to identify genetic loci as key targets of interventions and to develop monitoring and surveillance tools that are crucial for the successful elimination and eradication of malaria.

引用

页码：315 / 328

页数：14

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