Post-transplant lymphoproliferative disorders after heart or kidney transplantation at a single centre: Presentation and response to treatment

被引：5
|
作者：
Aversa, S. M. L. [1 ]
Stragliotto, S. [1 ]
Marino, D. [1 ]
Calabrese, F. [3 ]
Rigotti, P. [4 ]
Marchini, F. [4 ]
Gambino, A. [5 ]
Feltrin, G. [5 ]
Boso, C. [2 ]
Canova, F. [1 ]
Solda, C. [1 ]
Mazzarotto, R. [2 ]
Burra, P. [6 ]
机构：
[1] IRCCS, Div Med Oncol, Ist Oncol Veneto, IT-35128 Padua, Italy
[2] IRCCS, Dept Radiotherapy, Ist Oncol Veneto, IT-35128 Padua, Italy
[3] Univ Padua, Dept Med Sci & Special Therapies, Padua, Italy
[4] Univ Padua, Kidney & Pancreas Transplantat Unit, Dept Med & Surg Sci, Padua, Italy
[5] Univ Padua, Dept Cardiothorac Sci, Padua, Italy
[6] Univ Padua, Dept Surg & Gastroenterol Sci, Padua, Italy
来源：
ACTA HAEMATOLOGICA | 2008年 / 120卷 / 01期
关键词：
post-transplant lymphoproliferative disorders; solid organ transplantation; weekly chemotherapy;
D O I：
10.1159/000155234
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Post-transplant lymphoproliferative disorders (PTLD) is a serious complication after solid organ transplantation. Reduction of immunosuppression (RI) alone is not able to control the disease. We report a prospective analysis of 30 patients with PTLD after heart or kidney transplantation. Only 5 of 30 patients, treated solely with RI, obtained a complete response. Five patients were treated heterogeneously; in the remaining 20, the efficacy and safety of a weekly anthracycline-based chemotherapy were assessed. Sixteen patients obtained a complete remission. One death was related to treatment. With a median follow-up of 36 months, 3-year overall survival was 63.3% and 57% for the entire group and the chemotherapy-treated group, respectively. Moreover, 4 second neoplasms were observed in the chemotherapeutic group. In this study, we demonstrated that most PTLD need other treatment than RI and a weekly regimen is manageable and has a favourable impact on long-term survival. Copyright (C) 2008 S. Karger AG, Basel.
引用
收藏
页码：36 / 46
页数：11
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