Ophiosphaerellins A-I, Polyketide-Derived Compounds from the Endolichenic Fungus Ophiosphaerella korrae

被引：12

作者：

Li, Yuelan ^{[1
]}

Zhu, Rongxiu ^{[2
]}

Zhang, Jiaozhen ^{[1
]}

Xie, Fei ^{[1
]}

Wang, Xiaoning ^{[1
]}

Xu, Ke ^{[1
]}

Qiao, Yanan ^{[1
]}

Zhao, Zuntian ^{[3
]}

Lou, Hongxiang ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Dept Nat Prod Chem, Key Lab Chem Biol MOE, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Sch Chem & Chem Engn, 27 Shanda Nanlu, Jinan 250100, Shandong, Peoples R China

[3] Shandong Normal Univ, Coll Life Sci, 88 East Wenhua Rd, Jinan 250014, Shandong, Peoples R China

来源：

ACS OMEGA | 2018年 / 3卷 / 01期

基金：

中国国家自然科学基金;

关键词：

BIOSYNTHESIS;

D O I：

10.1021/acsomega.7b01668

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ophiosphaerellins A-I (1-9), the first example of bicyclo[4.1.0] heptenones, as well as their biosynthetic relatives ophiosphaerekorrins A-B (10-11) were isolated from the endolichenic fungus Ophiosphaerella korrae. Biosynthetically, they were derived from the polyketide pathway, and their absolute configurations were determined on the basis of the combination analysis of spectral data, circular dichroism calculations, and single-crystal X-ray diffraction measurement. Preliminary test with thin-layer chromatography bioautography found that this type of compounds showed moderate acetylcholinesterase (AChE) inhibitory effects.

引用

页码：176 / 180

页数：5

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